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首页> 美国卫生研究院文献>International Journal of Nephrology >Comparison of Measured Creatinine Clearance and Clearances Estimated by Cockcroft-Gault and MDRD Formulas in Patients with a Single Kidney
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Comparison of Measured Creatinine Clearance and Clearances Estimated by Cockcroft-Gault and MDRD Formulas in Patients with a Single Kidney

机译：测得的肌酐清除率与单肾患者用Cockcroft-Gault和MDRD公式估算的清除率的比较

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There are doubts about whether the values obtained from the Cockroft-Gault (ClCG) and Modification of Diet in Renal Disease (GFRMDRD) formulas are comparable to the more traditional formula used to obtain the creatinine clearance from a 24-hour urine collection (ClCrm), particularly in patients with only one kidney. The present study aimed to compare these formulas in individuals with one remaining kidney after previous nephrectomy (Nx) and to verify which estimated formula correlates more closely with ClCrm. Thirty-six patients who had undergone Nx had their renal filtration analyzed with ClCG, GFRMDRD and by ClCrm. The average time after Nx was 11.6 ± 9.0 years, and the average age at the time of the study was 50.7 ± 10.6 years old (X ± SD). The results of three clearances were 81.1 ± 35.6 mL·min·m2 for ClCrm, 70.4 ± 24.0 mL·min·m2 for ClCrCG, and 71.2 ± 19.2 mL·min·m2 for GFRMDRD (with ClCrm > ClCrCG and GFRMDRD; P < .001). No difference was found between the ClCrCG and GFRMDRD values (P = .72). The data demonstrated that both estimate formulas were strongly correlated with ClCrm, although ClCrCG was more closely associated with ClCrm than GFRMDRD (ClCrCG with r2 : 0.64 and GFRMDRD with r2 : 0.34; P < .001). In conclusion, for people with only one kidney remaining after NX, our data showed that glomerular filtration rate estimation by ClCrCG is more related to the values obtained with the traditional clearance measurement based on a 24-hour urine collection test.
机译：怀疑是否从Cockroft-Gault（ClCG）和肾脏疾病饮食调整（GFRMDRD）公式获得的值是否可与用于从24小时尿液收集中获得肌酐清除率的更传统的公式（ClCrm）相提并论。 ，尤其是只有一个肾脏的患者。本研究旨在比较先前肾切除术（Nx）后仅剩一个肾脏的个体中的这些公式，并验证哪个估计公式与ClCrm更紧密相关。 36例行Nx的患者通过ClCG，GFRMDRD和ClCrm分析了肾脏滤过情况。 Nx术后的平均时间为11.6±9.0岁，研究时的平均年龄为50.7±10.6岁（X±SD）。三个清除率的结果分别为：ClCrm为81.1±35.6 3mL·min·m 2 ，ClCrCG为70.4±24.0 mL·min·m 2 和71.2±19.2 mL· min·m 2 对于GFRMDRD（ClCrm> ClCrCG和GFRMDRD； P <.001）。 ClCrCG和GFRMDRD值之间未发现差异（P = .72）。数据表明，两个估计公式都与ClCrm密切相关，尽管与CFR相比，ClCr CG 与ClCr m 的关联更紧密（ClCr < sub 的r 2 ：0.64和GFR MDRD 的r 2 ：0.34; P <.001）。总之，对于NX后仅剩一个肾脏的人，我们的数据表明，ClCr CG 估计的肾小球滤过率与传统的基于24小时尿液的清除率测量值有关收集测试。

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