Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system

机译：通过超饱和自微乳化药物递送系统改善了水溶性差的靛玉红的口服生物利用度

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摘要

BackgroundIndirubin, isolated from the leaves of the Chinese herb Isatis tinctoria L, is a protein kinase inhibitor and promising antitumor agent. However, the poor water solubility of indirubin has limited its application. In this study, a supersaturatable self-microemulsifying drug delivery system (S-SMEDDS) was developed to improve the oral bioavailability of indirubin.

机译：背景靛玉红素是从中草药Isatis tinctoria L的叶子中分离出来的，它是一种蛋白激酶抑制剂和有希望的抗肿瘤剂。但是，靛玉红的水溶性差，限制了其应用。在这项研究中，开发了一种超饱和自微乳化药物递送系统（S-SMEDDS），以提高靛玉红的口服生物利用度。

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期刊名称 International Journal of Nanomedicine
作者
Zhi-Qiang Chen; Ying Liu; Ji-Hui Zhao; Lan Wang; Nian-Ping Feng;
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作者单位

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年(卷),期 2012(7),-1
年度 2012
页码 1115–1125
总页数 11
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
supersaturatable self-microemulsifying drug delivery system indirubin bioavailability oral drug delivery hydrophilic polymer;

机译：超饱和自微乳化给药系统;靛玉红;生物利用度;口服给药;亲水性聚合物;

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专利

1. Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system [J] . Zhi-Qiang Chen, Ying Liu, Ji-Hui Zhao, International Journal of Nanomedicine . 2012,第9期

机译：超饱和自微乳化药物递送系统改善了水溶性差的靛玉红的口服生物利用度
2. Co-delivery of natural metabolic inhibitors in a self-microemulsifying drug delivery system for improved oral bioavailability of curcumin [J] . GrillA.E., KoniarB., PanyamJ. Drug delivery and translational research . 2014,第4期

机译：在自微乳化药物输送系统中共同输送天然代谢抑制剂，以改善姜黄素的口服生物利用度
3. Improved oral bioavailability of myricitrin by liquid self-microemulsifying drug delivery systems [J] . Na Man, Qilong Wang, Huihua Li, Journal of drug delivery science and technology . 2019,第期

机译：通过液体自微乳化药物递送系统改善冬青林的口服生物利用度
4. Development of self-microemulsifying drug delivery systems (SMEDDS)for improving oral bioavailability of Ginkgo biloba extract in dogs [C] . Zhong-gui He, Jing-ling Tang, Jin Sun, Annual meeting exposition of the Controlled Release Society . 2005

机译：开发用于改善狗银杏叶提取物口服生物利用度的自微乳化药物递送系统（SMEDDS）
5. Development and characterization of a solid self-microemulsifying drug delivery system (SMEDDS) of albendazole and evaluation of oral bioavailability in rabbits. [D] . Mukherjee, Tusharmouli. 2010

机译：阿苯达唑固体自微乳化药物递送系统（SMEDDS）的开发和表征以及兔口服生物利用度的评估。
6. CO-DELIVERY OF NATURAL METABOLIC INHIBITORS IN A SELF-MICROEMULSIFYING DRUG DELIVERY SYSTEM FOR IMPROVED ORAL BIOAVAILABILITY OF CURCUMIN [O] . Alex E. Grill, Brenda Koniar, Jayanth Panyam -1

机译：天然代谢抑制剂在自体微丸化药物递送系统中的共递送可提高姜黄素的口服生物利用度
7. Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system [O] . Chen, Zhi-Qiang, Liu, Ying, Zhao, Ji-Hui, 2012

机译：通过超饱和自微乳化药物递送系统改善了水溶性差的靛玉红的口服生物利用度

Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system

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