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首页> 美国卫生研究院文献>International Journal of Nanomedicine >Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment
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Photothermal transforming agent and chemotherapeutic co-loaded electrospun nanofibers for tumor treatment

机译：光热转化剂和化学共载电纺丝纳米纤维用于肿瘤治疗

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>Background: Photothermal and chemotherapy treatment has been frequently studied for cancer therapy; however, chemotherapy is equally toxic to both normal and cancer cells. The clinical application value of most kinds of photothermal transforming agents remains limited, due to their poor degradation and minimal accumulation in tumors.>Materials and methods: We reported the synthesis of photothermal transforming agents (MoS2) and chemotherapeutic (doxorubicin, DOX) co-loaded electrospun nanofibers using blend electrospinning for the treatment of postoperative tumor recurrence.>Results: Under the irradiation of an 808 nm laser, the as-prepared chitosan/polyvinyl alcohol/MoS2/DOX nanofibers showed an admirable photothermal conversion capability with a photothermal conversion efficiency of 23.2%. These composite nanofibers are in vitro and in vivo biocompatible. In addition, they could control the sustained release of DOX and the generated heat can sensitize the chemotherapeutic efficacy of DOX via enhancing its release rate. Their chemo-/photothermal combined therapy efficiency was systematically studied in vitro and in vivo. Instead of circulating with the body fluid, MoS2 was trapped by the nanofibrous matrix in the tumor and so its tumor-killing ability was not compromised, thus rendering this composite nanofiber a promising alternative for future clinical translation within biomedical application fields.>Conclusion: Chitosan/polyvinyl alcohol/MoS2/DOX nanofibers showed an excellent photothermal conversion capability with a photothermal conversion efficiency of 23.2% and can completely inhibit the postoperative tumor reoccurrence.
机译：>背景：光热和化学疗法已被广泛用于癌症治疗。然而，化学疗法对正常细胞和癌细胞均具有同等毒性。由于大多数光热转化剂在肿瘤中的降解能力较弱和积累最少，因此其临床应用价值仍然有限。>材料和方法：我们报道了光热转化剂（MoS2）的合成和化学治疗（ >结果：在808 nm激光照射下，制备的壳聚糖/聚乙烯醇/ MoS2 / DOX共同负载了静电纺丝纳米纤维，并采用混合电纺丝技术治疗术后肿瘤复发。纳米纤维表现出令人钦佩的光热转化能力，光热转化效率为23.2％。这些复合纳米纤维具有体外和体内生物相容性。此外，它们可以控制DOX的持续释放，并且产生的热量可以通过提高DOX的释放速率来敏化DOX的化疗功效。在体外和体内系统地研究了它们的化学/光热联合治疗效率。 MoS2不会随体液循环，而是被纳米纤维基质捕获在肿瘤中，因此其杀肿瘤能力没有受到损害，因此使这种复合纳米纤维成为生物医学应用领域中未来临床翻译的有希望的替代方法。>结论：壳聚糖/聚乙烯醇/ MoS2 / DOX纳米纤维具有优异的光热转化能力，光热转化效率为23.2％，可以完全抑制术后肿瘤的复发。

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