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首页> 美国卫生研究院文献>International Journal of Nanomedicine >Photothermal conversion hydrogel based mini-eye patch for relieving dry eye with long-term use of the light-emitting screen
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Photothermal conversion hydrogel based mini-eye patch for relieving dry eye with long-term use of the light-emitting screen

机译：长期使用发光屏的基于光热转换水凝胶的迷你眼贴剂可缓解干眼症

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>Purpose: The frequent usage of various lighting screens has made dry eye syndrome an increasingly serious phenomenon. To relieve this global problem, we have developed a photothermal conversion hydrogel based mini-eye patch.>Methods: Gold nanoparticles (GNRs) were synthesized by a seed-mediated method, and then used as the inner cores to grow palladium (Pd) shell by PdCl42-reduction. Then, gelatin was added to prepare GNRs @ Pd hydrogel eye patch by genipin cross-linking. We implanted temperature sensitive ink (complex composed of amino resin and styrene maleic anhydride copolymer) in the eye patch, which could change color at different temperatures. Heating performance of the eye patch was accessed with an infrared temperature profile and the circulating temperature experiment. The safety assessment of the eye patch was conducted by H&E staining of the mouse’s eyelid skin and CCK-8 assay. A Keratograph 5M noninvasive ocular surface analyzer was used to assess the impact of eye patches on dry eyes.>Results: It was found that GNRs @ Pd hydrogel eye patches could sense various visible light and responded by heating up spontaneously. Results from the CCK-8 assay and H&E staining showed that the eye patch has good safety performance. Measurements of the first noninvasive tear break-up time (NITBUT), the average NITBUT, the tear meniscus height (TMH), combined with red eye analysis, further demonstrated the patch’s eye-protective properties.>Conclusion: After being pasted to the lacrimal gland, the hydrogel patch converted various light irradiations into heat and stimulated the lacrimal gland to produce more tears to relieve dry eye. The built-in temperature-sensitive ink can play an important role in warning people of their excessive eye usage. Because this recyclable strategy does not interfere with normal eye use, it is thus more environmentally friendly and convenient than ordinary infrared eyewear.
机译：>目的：各种照明屏幕的频繁使用已使干眼症成为日益严重的现象。为了缓解这一全球性问题，我们开发了一种基于光热转换水凝胶的迷你眼贴。>方法：通过种子介导的方法合成金纳米颗粒（GNR），然后将其用作内芯。通过PdCl42还原生长钯（Pd）壳。然后，加入明胶通过genipin交联制备GNRs @ Pd水凝胶眼贴。我们在眼罩中植入了温度敏感型墨水（由氨基树脂和苯乙烯马来酸酐共聚物组成的复合物），它可以在不同温度下改变颜色。通过红外温度曲线和循环温度实验来了解眼罩的加热性能。眼贴的安全性评估是通过对小鼠的眼睑皮肤进行H＆E染色和CCK-8分析来进行的。使用Keratograph 5M非侵入性眼表分析仪评估眼罩对干眼的影响。>结果：发现，GNRs @ Pd水凝胶眼罩可感知各种可见光并通过自发加热做出响应。 CCK-8分析和H＆E染色的结果表明，该眼罩具有良好的安全性能。对第一个非侵入性泪液破裂时间（NITBUT），平均NITBUT，泪液半月板高度（TMH）的测量与红眼分析相结合，进一步证明了该贴剂的护眼特性。>结论：在粘贴到泪腺后，水凝胶贴剂将各种光照射转化为热量，并刺激泪腺产生更多的眼泪以缓解干眼症。内置的热敏墨水在警告人们过度使用眼睛方面可以发挥重要作用。由于这种可回收利用的策略不会干扰正常的眼睛使用，因此它比普通的红外眼镜更环保，更方便。

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