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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines—Flos Lonicerae Japonicae—Fructus Forsythiae Herb Couples as an Example
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Discovery and Current Status of Evaluation System of Bioavailability and Related Pharmaceutical Technologies for Traditional Chinese Medicines—Flos Lonicerae Japonicae—Fructus Forsythiae Herb Couples as an Example

机译：中药生物利用度及相关制药技术评价体系的发现与现状-以金银花连翘药材夫妇为例

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摘要

Traditional Chinese medicines (TCMs) have attracted extensive interest throughout the world due to their long history of health protection and disease control, and the internalization of TCM preparations or patented drugs has been considered a wind vane in the process of TCM modernization. However, multi-target effects, caused by multiple components in TCMs, hinder not only the construction of the quality evaluation system (bioavailability), but also the application of pharmaceutical technologies, which results in the poor efficacy in clinical practice. This review describes the methods in the literature as well as in our thoughts about how to identify the marker components, establish the evaluation system of bioavailability, and improve the bioavailability in TCM preparations. We expect that the current study will be positive and informative.
机译：传统中药（TCM）由于其悠久的健康保护和疾病控制历史而引起了全世界的广泛关注，并且中药制剂或专利药物的内部化已被视为中药现代化进程中的风向标。然而，由中药中多种成分引起的多靶点作用不仅阻碍了质量评价体系（生物利用度）的构建，而且也阻碍了药物技术的应用，导致临床实践中疗效较差。这篇综述描述了文献中的方法以及我们关于如何鉴定标记物成分，建立生物利用度评估系统以及提高中药制剂生物利用度的思想。我们希望当前的研究将是积极和有益的。

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