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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >A Potent Antifungal Agent for Basal Stem Rot Disease Treatment in Oil Palms Based on Chitosan-Dazomet Nanoparticles
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A Potent Antifungal Agent for Basal Stem Rot Disease Treatment in Oil Palms Based on Chitosan-Dazomet Nanoparticles

机译：基于壳聚糖-达唑米特纳米粒子的强效抗真菌剂用于治疗油棕基底茎腐烂病

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The use of nanotechnology could play a significant role in the agriculture sector, especially in the preparation of new-generation agronanochemicals. Currently, the economically important plant of Malaysia, the oil palm, faces the threat of a devastating disease which is particularly caused by a pathogenic fungus, Ganoderma boninense. For the development of an effective antifungal agent, a series of chitosan nanoparticles loaded with a fumigant, dazomet, were prepared using various concentrations of sodium tripolyphosphate (TPP)—2.5, 5, 10, and 20 mg/mL, abbreviated as CDEN2.5, CDEN5, CDEN10, and CDEN20, respectively. The effect of TPP as a crosslinking agent on the resulting particle size of the synthesized nanoparticles was investigated using a particle size analyzer and high-resolution transmission electron microscopy (HRTEM). Both methods confirmed that increasing the TPP concentration resulted in smaller particles. In addition, in vitro fumigant release at pH 5.5 showed that the release of the fumigant from the nanoparticles was of a sustained manner, with a prolonged release time up to 24 h. Furthermore, the relationship between the chitosan-dazomet nanoparticles and the in vitro antifungal activity against G. boninense was also explored, where the nanoparticles of the smallest size, CDEN20, gave the highest antifungal efficacy with the lowest half maximum effective concentration (EC50) value of 13.7 ± 1.76 ppb. This indicates that the smaller-sized agronanoparticles were more effective as an antifungal agent. The size can be altered, which plays a crucial role in combatting the Ganoderma disease. The agronanoparticles have controlled release properties and high antifungal efficacy on G. boninense, thus making them a promising candidate to be applied in the field for Ganoderma treatment.
机译：纳米技术的使用可能在农业部门，尤其是在制备新一代农用化学药品中发挥重要作用。目前，马来西亚具有重要经济意义的植物油棕面临着毁灭性疾病的威胁，这种疾病尤其是由致病性真菌灵芝boninense引起的。为了开发有效的抗真菌剂，使用各种浓度的三聚磷酸钠（TPP）-2.5、5、10和20 mg / mL（缩写为CDEN2.5）制备了一系列装有熏蒸剂dazomet的壳聚糖纳米颗粒。 ，CDEN5，CDEN10和CDEN20。使用粒度分析仪和高分辨率透射电子显微镜（HRTEM）研究了TPP作为交联剂对合成纳米颗粒的最终粒度的影响。两种方法均证实增加TPP浓度可产生较小的颗粒。此外，pH 5.5的体外熏蒸剂释放表明，熏蒸剂从纳米颗粒的释放是持续的，释放时间长达24小时。此外，还探讨了壳聚糖-重氮酰胺纳米颗粒与体外对博尼特菌的抗真菌活性之间的关系，其中最小尺寸的CDEN20纳米颗粒具有最高的抗真菌功效，最低的最大有效浓度（EC50）值最低。 13.7±1.76 ppb。这表明较小尺寸的农用纳米颗粒作为抗真菌剂更有效。大小可以改变，这在对抗灵芝疾病中起着至关重要的作用。所述农杆菌纳米颗粒具有对释放的灵芝G.boninense的控制释放特性和高抗真菌功效，因此使其成为在灵芝治疗领域中应用的有希望的候选者。

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