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首页> 美国卫生研究院文献>International Journal of Medical Sciences >Chlorophytum borivilianum Root Extract Maintains near Normal Blood Glucose Insulin and Lipid Profile Levels and Prevents Oxidative Stress in the Pancreas of Streptozotocin-Induced Adult Male Diabetic Rats
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Chlorophytum borivilianum Root Extract Maintains near Normal Blood Glucose Insulin and Lipid Profile Levels and Prevents Oxidative Stress in the Pancreas of Streptozotocin-Induced Adult Male Diabetic Rats

机译：小球藻根提取物保持接近正常的血糖胰岛素和脂质水平并预防链脲佐菌素诱导的成年雄性糖尿病大鼠胰腺的氧化应激

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摘要

The effect of C. borivilianum root on blood glucose, glycated hemoglobin (HbAIc), insulin and lipid profile levels in diabetes mellitus are not fully understood. This study therefore investigated the effect of C. borivilianum root on the above parameters and oxidative stress of the pancreas in diabetes. Methods: C. borivilianum root aqueous extract (250 and 500 mg/kg/day) was administered to streptozotocin (STZ)-induced male diabetic rats for 28 days. Body weight, blood glucose, HbA1c, insulin, lipid profile levels and glucose homeostasis indices were determined. Histopathological changes and oxidative stress parameters i.e. lipid peroxidation (LPO) and antioxidant enzymes activity levels of the pancreas were investigated. Results: C. borivilianum root extract treatment to diabetic rats maintained near normal body weight, blood glucose, HbA1c, lipid profile and insulin levels with higher HOMA-β cell functioning index, number of Islets/pancreas, number of β-cells/Islets however with lower HOMA-insulin resistance (IR) index as compared to non-treated diabetic rats. Negative correlations between serum insulin and blood glucose, HbA1c, triglyceride (TG) and total cholesterol (TC) levels were observed. C. borivilianum root extract administration prevented the increase in lipid peroxidation and the decrease in activity levels of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) with mild histopathological changes in the pancreas of diabetic rats. Conclusions: C. borivilianum root maintains near normal levels of these metabolites and prevented oxidative stress-induced damage to the pancreas in diabetes.
机译：尚无完全了解鲍氏梭菌根对糖尿病患者血糖，糖化血红蛋白（HbAlc），胰岛素和脂质分布水平的影响。因此，本研究调查了牛膝衣原体根对糖尿病上述参数和胰腺氧化应激的影响。方法：对链脲佐菌素（STZ）诱导的雄性糖尿病大鼠施用牛膝衣原体根水提取物（250和500 mg / kg /天）28天。测定体重，血糖，HbA1c，胰岛素，脂质分布水平和葡萄糖稳态指数。研究了胰腺的组织病理学变化和氧化应激参数，即脂质过氧化（LPO）和抗氧化酶活性水平。结果：糖尿病大鼠的葡萄球菌根提取物治疗保持了接近正常的体重，血糖，HbA1c，脂质分布和胰岛素水平，但HOMA-β细胞功能指数更高，胰岛/胰脏数目，β细胞/胰岛数目与未治疗的糖尿病大鼠相比，具有较低的HOMA-胰岛素抵抗（IR）指数。观察到血清胰岛素与血糖，HbA1c，甘油三酸酯（TG）和总胆固醇（TC）水平呈负相关。在糖尿病大鼠胰腺中，C。borivilianum根提取物的施用可防止脂质过氧化的增加以及超氧化物歧化酶（SOD），过氧化氢酶（CAT）和谷胱甘肽过氧化物酶（GPx）活性水平的降低，并具有轻度的组织病理学改变。结论：梭状芽胞杆菌根维持这些代谢物的接近正常水平，并防止氧化应激诱导的糖尿病胰腺损害。

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