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首页> 美国卫生研究院文献>International Journal of Endocrinology >Relation of Epicardial Fat Thickness with Carotid Intima-Media Thickness in Patients with Type 2 Diabetes Mellitus
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Relation of Epicardial Fat Thickness with Carotid Intima-Media Thickness in Patients with Type 2 Diabetes Mellitus

机译：2型糖尿病患者心外膜脂肪厚度与颈动脉内膜中膜厚度的关系

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Aims. The aim of this study was to investigate the relationship of echocardiographic epicardial fat thickness (EFT) with carotid intima-media thickness (CIMT), in patients with type 2 diabetes mellitus (T2DM). Methods and Results. A total of 139 patients with T2DM (mean age 54.3 ± 9.2 and 49.6% male) and 40 age and sex-matched control subjects were evaluated. Echocardiographic EFT and ultrasonographic CIMT were measured in all subjects. Patients with T2DM had significantly increased EFT and CIMT than those of the controls (6.0 ± 1.5 mm versus 4.42 ± 1.0 mm, P < 0.001 and 0.76 ± 0.17 mm versus 0.57 ± 0.14 mm, P < 0.001, resp.). EFT was correlated with CIMT, waist circumference, BMI, age, duration of T2DM, HbA1c in the type 2 diabetic patients. Linear regression analysis showed that CIMT (β = 3.52, t = 3.72, P < 0.001) and waist circumference (β = 0.36, t = 2.26, P = 0.03) were found to be independent predictors of EFT. A cutoff high risk EFT value of 6.3 mm showed a sensitivity and specificity of 72.5% and 71.7%, respectively, for the prediction of subclinical atherosclerosis. Conclusion. We found that echocardiographic EFT was significantly higher in patients with T2DM. Our study also showed that EFT was strongly correlated with waist circumference and CIMT as being independent of sex.
机译：目的这项研究的目的是调查2型糖尿病（T2DM）患者的超声心动图心外膜脂肪厚度（EFT）与颈动脉内膜中层厚度（CIMT）的关系。方法和结果。总共评估了139例T2DM患者（平均年龄54.3±9.2和男性的49.6％）以及40位年龄和性别匹配的对照受试者。在所有受试者中均测量了超声心动图EFT和超声CIMT。与对照组相比，T2DM患者的EFT和CIMT显着增加（6.0±1.5mm对4.42±1.0mm，P <0.001和0.76±0.17mm对0.57±0.14mm，P <0.001）。 2型糖尿病患者的EFT与CIMT，腰围，BMI，年龄，T2DM持续时间，HbA1c相关。线性回归分析表明，CIMT（β= 3.52，t = 3.72，P <0.001）和腰围（β= 0.36，t = 2.26，P = 0.03）是EFT的独立预测因子。临界高风险EFT值为6.3mm，对于预测亚临床动脉粥样硬化的敏感性和特异性分别为72.5％和71.7％。结论。我们发现，T2DM患者的超声心动图EFT明显更高。我们的研究还表明，EFT与腰围和CIMT密切相关，与性别无关。

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