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首页> 美国卫生研究院文献>International Journal of Endocrinology >Predictors of the Dose-Effect Relationship regarding Unilateral Inferior Rectus Muscle Recession in Patients with Thyroid Eye Disease
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Predictors of the Dose-Effect Relationship regarding Unilateral Inferior Rectus Muscle Recession in Patients with Thyroid Eye Disease

机译：甲状腺眼疾病患者单侧下直肌下退的剂量-效应关系的预测因子

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Purpose. To evaluate whether inferior rectus muscle (IRM) thickness, the degree of adipose change in the IRM, smoking status, and the previous history of orbital radiotherapy can predict the dose-effect relationship regarding unilateral IRM recession in thyroid eye disease (TED). Methods. Twenty-five patients were retrospectively reviewed. We calculated the largest IRM cross-sectional area and evaluated the degree of adipose change in the IRM using magnetic resonance imaging. The degree of adipose change and smoking status were classified using grading scales (0–3); previous orbital radiotherapy was graded as 0 when a history was not available and 1 when it was available. The correlation between the dose-effect relationship and the hypothesized predictive factors was evaluated using stepwise multiple regression analysis. Results. The multiple regression model, with the exception of the history of the previous orbital radiotherapy, estimated a significant dose-effect relationship for the parameters evaluated (Y DOSE-EFFECT = 0.013X IRM AREA  − 0.222X ADIPOSE  − 0.102X SMOKING + 1.694; r = 0.668; adjusted r 2 = 0.367; P = 0.005). Conclusions. The dose-effect relationship regarding unilateral IRM recession in TED could be predicted using IRM thickness, degree of intramuscular adipose change, and smoking status but could not be predicted using the previous orbital radiotherapy history.
机译：目的。为了评估下直肌（IRM）厚度，IRM的脂肪变化程度，吸烟状况以及先前的轨道放疗史，是否可以预测甲状腺眼病（TED）中单侧IRM衰退的剂量-效应关系。方法。回顾性分析了25例患者。我们计算了最大的IRM横截面积，并使用磁共振成像评估了IRM中的脂肪变化程度。脂肪变化程度和吸烟状况使用等级量表（0-3）进行分类。既往无病史，以前的轨道放疗等级为0，有病史的等级为1。使用逐步多元回归分析评估剂量效应关系与假设的预测因素之间的相关性。结果。除先前的轨道放疗史外，多元回归模型估计出所评估参数的显着剂量效应关系（Y DOSE-EFFECT = 0.013X IRM AREA-0.222X ADIPOSE-0.102X吸烟+ 1.694; r = 0.668；调整后的r 2 = 0.367； P = 0.005）。结论。可以使用IRM厚度，肌肉内脂肪变化的程度和吸烟状况来预测TED中单侧IRM衰退的剂量效应关系，但不能使用先前的轨道放疗历史来预测。

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