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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >Radioactive Iodide (131I−) Excretion Profiles in Response to Potassium Iodide (KI) and Ammonium Perchlorate (NH4ClO4) Prophylaxis
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Radioactive Iodide (131I−) Excretion Profiles in Response to Potassium Iodide (KI) and Ammonium Perchlorate (NH4ClO4) Prophylaxis

机译：预防碘化钾（KI）和高氯酸铵（NH4ClO4）的放射性碘（131I-）排泄特征

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Radioactive iodide (131I−) protection studies have focused primarily on the thyroid gland and disturbances in the hypothalamic-pituitary-thyroid axis. The objective of the current study was to establish 131I− urinary excretion profiles for saline, and the thyroid protectants, potassium iodide (KI) and ammonium perchlorate over a 75 hour time-course. Rats were administered 131I− and 3 hours later dosed with either saline, 30 mg/kg of NH4ClO4 or 30 mg/kg of KI. Urinalysis of the first 36 hours of the time-course revealed that NH4ClO4 treated animals excreted significantly more 131I− compared with KI and saline treatments. A second study followed the same protocol, but thyroxine (T4) was administered daily over a 3 day period. During the first 6–12 hour after 131I− dosing, rats administered NH4ClO4 excreted significantly more 131I− than the other treatment groups. T4 treatment resulted in increased retention of radioiodide in the thyroid gland 75 hour after 131I− administration. We speculate that the T4 treatment related reduction in serum TSH caused a decrease synthesis and secretion of thyroid hormones resulting in greater residual radioiodide in the thyroid gland. Our findings suggest that ammonium perchlorate treatment accelerates the elimination rate of radioiodide within the first 24 to 36 hours and thus may be more effective at reducing harmful exposure to 131I− compared to KI treatment for repeated dosing situations. Repeated dosing studies are needed to compare the effectiveness of these treatments to reduce the radioactive iodide burden of the thyroid gland.
机译：放射性碘（ 131 I -）保护研究主要集中在甲状腺和下丘脑-垂体-甲状腺轴的干扰。本研究的目的是在75小时内建立盐水的 131 I -尿排泄图以及甲状腺保护剂，碘化钾（KI）和高氯酸铵-课程。给大鼠 131 I -，并在3小时后给其注射生理盐水，30 mg / kg NH4ClO4或30 mg / kg KI。时间段前36小时的尿液分析显示，与KI和生理盐水处理相比，用NH4ClO4处理的动物排泄的 131 I -多得多。第二次研究遵循相同的方案，但是甲状腺素（T4）在3天的时间内每天给药。在 131 I -给药后的最初6–12小时内，施用NH4ClO4的大鼠排泄的 131 I -明显更多。比其他治疗组。在给予 131 I -后75小时，T4处理导致放射性碘在甲状腺中的保留增加。我们推测，与T4治疗相关的血清TSH降低导致甲状腺激素合成和分泌减少，从而导致甲状腺中残留的放射性碘更高。我们的发现表明，高氯酸铵处理可在头24到36小时内加快放射性碘的清除速度，因此与 131 I -相比，在减少有害暴露方面可能更有效。 KI治疗可重复使用。需要重复剂量研究以比较这些治疗方法减轻甲状腺放射性碘化物负担的有效性。

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