Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis

机译：气相色谱串联质谱为尿类固醇分析提供优势

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摘要

Gas chromatography mass spectrometry has been the lynchpin of clinical assessment of steroid profiles for ∼3 decades. The improvements in assay performance offered by tandem mass spectrometry were assessed. Across the spectrum of glucocorticoid and androgen analytes tested, limits of detection and quantitation were ∼20 fold lower with triple than single quadrupole systems, but the more noticeable improvement was that signal to noise was substantially improved and the linear range wider. These benefits allowed more reliable and concomitant measurement of steroids with substantially different abundances and in smaller volumes of urine.

机译：气相色谱质谱法一直是临床评估类固醇激素谱的关键，大约持续了三十年。评估了串联质谱在分析性能方面的改进。在测试的糖皮质激素和雄激素分析物的整个光谱范围内，三重检测和定量检测的限度比单四极杆系统低约20倍，但更明显的改善是信噪比得到了显着改善，线性范围更宽。这些好处使人们可以更可靠，更准确地测量丰度明显不同且尿液量较小的类固醇。

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期刊名称 Elsevier Sponsored Documents
作者
Natalie Homer; Sanjay Kothiya; Alison Rutter; Brian R. Walker; Ruth Andrew;
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作者单位

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年(卷),期 -1(538),-1
年度 -1
页码 34–37
总页数 4
原文格式 PDF
正文语种
中图分类
关键词
Steroid Triple quadrupole Tandem mass spectrometry Urine Corticosteroid Androgen;

机译：类固醇;三重四极杆;串联质谱;尿液;皮质类固醇;雄激素;

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专利

1. Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis [J] . Natalie Homer, Sanjay Kothiya, Alison Rutter, Analytical Biochemistry: An International Journal of Analytical and Preparative Methods . 2017,第期

机译：气相色谱串联质谱仪为尿液固醇分析提供优势
2. Determination of anabolic steroids by gas chromatography negative-ion chemical ionization mass spectrometry and gas chromatography negative-ion chemical ionization tandem mass spectrometry with heptafluorobutyric anhydride derivatization [J] . Choi MH., Lee W., Lee UC., Rapid Communications in Mass Spectrometry: RCM . 1999,第5期

机译：气相色谱负离子化学电离质谱和七氟丁酸酐衍生化气相色谱负离子化学电离串联质谱法测定合成代谢类固醇
3. Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS). [J] . Krone N, Hughes BA, Lavery GG, The Journal of Steroid Biochemistry and Molecular Biology . 2010,第3a5期

机译：即使在快速液相色谱串联质谱分析（LC / MS / MS）时代，气相色谱/质谱（GC / MS）仍是临床类固醇研究中的主要发现工具。
4. A simplified and accurate method for the analysis of urinary metabolites of testosterone-related steroids using gas chromatography-combustion-isotope ratio mass spectrometry [C] . Alexandre Ouellet, Nicolas LeBerre, Christiane Ayotte American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2013

机译：一种简化且准确的方法，用于分析睾酮相关类固醇的尿代谢物使用气相色谱 - 燃烧 - 同位素比率质谱法
5. Analytical method development for the detection of the metabolites of the hormonal steroids trenbolone acetate and melengestrol acetate in complex environmental matrices using gas chromatography/tandem mass spectrometry. [D] . Parker, Jed Arthur. 2009

机译：气相色谱/串联质谱法在复杂环境基质中检测激素类固醇乙酸群勃龙和乙酸美仑孕酮的代谢物的分析方法的开发。
6. Gas chromatography/mass spectrometry (GC/MS) remains a pre-eminent discovery tool in clinical steroid investigations even in the era of fast liquid chromatography tandem mass spectrometry (LC/MS/MS) [O] . Nils Krone, Beverly A. Hughes, Gareth G. Lavery, -1

机译：即使在快速液相色谱串联质谱（LC / MS / MS）时代气相色谱/质谱（GC / MS）仍然是临床类固醇研究中的主要发现工具。
7. Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis [O] . Natalie Homer, Sanjay Kothiya, Alison Rutter, 2017

机译：气相色谱串联质谱为泌尿类固醇分析提供优势

Gas chromatography tandem mass spectrometry offers advantages for urinary steroids analysis

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