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首页> 美国卫生研究院文献>Evidence-based Complementary and Alternative Medicine : eCAM >Huperzine A in the Treatment of Alzheimers Disease and Vascular Dementia: A Meta-Analysis
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Huperzine A in the Treatment of Alzheimers Disease and Vascular Dementia: A Meta-Analysis

机译：石杉碱甲治疗阿尔茨海默氏病和血管性痴呆的Meta分析

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The objective of our study was to perform an updated meta-analysis of placebo-controlled RCTs of Huperzine A (Hup A) on patients with Alzheimer's disease (AD) and vascular dementia (VD), in order to provide the basis and reference for clinical rational drug use. The primary outcome measures assessed were minimental state examination (MMSE) and activities of daily living scale (ADL). Eight AD trials with 733 participants and two VD trials with 92 participants that met our inclusion criteria were identified. The results showed that Hup A could significantly improve the MMSE and ADL score of AD and VD patients, and longer durations would result in better efficacy for the patients with AD. It seemed that there was significant improvement of cognitive function measured by memory quotient (MQ) in patients with AD. Most adverse effects in AD were generally of mild to moderate severity and transient. Compared to the patients with AD, Hup A may offer fewer side effects for participants with VD in this study. Therefore, Hup A is a well-tolerated drug that could significantly improve cognitive performance in patients with AD or VD, but we need to use it with caution in the clinical treatment.
机译：我们研究的目的是对患有阿尔茨海默氏病（AD）和血管性痴呆（VD）的患者进行石杉碱甲（Hup A）安慰剂对照RCT的最新荟萃分析，以便为临床提供基础和参考合理用药。评估的主要结局指标是体格检查（MMSE）和日常活动量表（ADL）。确定了八项有733名参与者的AD试验和两项有92名参与者的VD试验，它们符合我们的纳入标准。结果表明，Hup A可以显着改善AD和VD患者的MMSE和ADL评分，持续时间越长，AD患者的疗效就越好。用记忆商（MQ）衡量的AD患者认知功能似乎有明显改善。 AD的大多数不良反应通常为轻度至中度严重度和短暂性。与AD患者相比，Hup A在这项研究中可能为VD参与者提供更少的副作用。因此，Hup A是一种耐受良好的药物，可以显着改善AD或VD患者的认知能力，但是在临床治疗中我们必须谨慎使用。

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