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首页> 美国卫生研究院文献>Experimental Diabetes Research >Microvesicles Correlated with Components of Metabolic Syndrome in Men with Type 2 Diabetes Mellitus and Lowered Testosterone Levels But Were Unaltered by Testosterone Therapy
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Microvesicles Correlated with Components of Metabolic Syndrome in Men with Type 2 Diabetes Mellitus and Lowered Testosterone Levels But Were Unaltered by Testosterone Therapy

机译：2型糖尿病男性患者与代谢综合征成分相关的微囊泡睾丸激素水平降低但睾丸激素治疗并未改变

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Aims. To investigate how circulating microvesicle phenotypes correlate with insulin sensitivity, body composition, plasma lipids, and hepatic fat accumulation. We hypothesized that changes elicited by testosterone replacement therapy are reflected in levels of microvesicles. Methods. Thirty-nine type 2 diabetic males with lowered testosterone levels were assigned to either testosterone replacement therapy or placebo and evaluated at baseline and after 24 weeks. Microvesicles were analysed by flow cytometry and defined as lactadherin-binding particles within the 0.1–1.0 μm gate. Microvesicles of platelet, monocyte, and endothelial cell origin were identified by cell-specific markers and their expression of CD36 was investigated. Results. Triglycerides correlated positively with all investigated microvesicle phenotypes in this study (p < 0.05), and indicators of hepatic fat accumulation, alanine aminotransferase, and gamma glutamyltransferase correlated with platelet and endothelial microvesicles and CD36-expressing microvesicles from platelets and monocytes (p < 0.05). BMI, waist circumference, and fat percentage correlated with CD36-expressing monocyte microvesicles (p < 0.05), while insulin sensitivity did not correlate with any microvesicle phenotypes. Microvesicle levels were unaffected by testosterone therapy. Conclusions. Metabolic syndrome components and hepatic fat accumulation correlated with microvesicle phenotypes, supporting the involvement of especially CD36 on monocytes in metabolic syndrome pathogenesis. Although testosterone therapy improved body composition measures, microvesicle phenotype levels were unaffected. This trial was registered at ClinicalTrials.gov ().
机译：目的研究循环微泡表型如何与胰岛素敏感性，身体组成，血浆脂质和肝脂肪蓄积相关。我们假设睾丸激素替代疗法引起的变化反映在微泡水平上。方法。降低睾丸激素水平的39名2型糖尿病男性被分配接受睾丸激素替代治疗或安慰剂，并在基线和24周后进行评估。通过流式细胞仪分析微囊泡，并将其定义为0.1–1.0μm门内的乳粘附素结合颗粒。通过细胞特异性标记鉴定血小板，单核细胞和内皮细胞来源的微泡，并研究其CD36的表达。结果。甘油三酸酯与本研究中所有研究的微泡表型呈正相关（p <0.05），肝脂肪蓄积，丙氨酸氨基转移酶和γ-谷氨酰转移酶的指标与血小板和内皮微泡以及血小板和单核细胞表达CD36的微泡相关（p <0.05） 。 BMI，腰围和脂肪百分比与表达CD36的单核细胞微囊泡相关（p <0.05），而胰岛素敏感性与任何微囊泡表型无关。微囊泡水平不受睾丸激素治疗的影响。结论。代谢综合征的成分和肝脏脂肪的积累与微泡表型相关，支持尤其是CD36参与代谢综合征发病机制中的单核细胞。尽管睾丸激素疗法改善了身体成分指标，但微泡表型水平未受影响。该试验已在ClinicalTrials.gov（）上注册。

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