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Soluble egg antigen of Schistosoma japonicum induces pyroptosis in hepatic stellate cells by modulating ROS production

机译：日本血吸虫的可溶性卵抗原通过调节ROS的产生诱导肝星状细胞的凋亡

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BackgroundInflammation-induced dysfunction of hepatic stellate cells (HSCs) is involved in schistosomiasis-associated liver fibrosis, and soluble egg antigen (SEA) is a crucial pathogen-associated molecular pattern associated with liver injury in schistosomiasis. In addition, numerous studies have shown that caspase-1-mediated pyroptosis participates in the development of multiple inflammation-related diseases. However, whether pyroptotic cell death of HSCs is involved in SEA-mediated liver damage is not well understood.

机译：背景炎症诱导的肝星状细胞（HSC）功能障碍与血吸虫病相关的肝纤维化有关，可溶性蛋抗原（SEA）是与血吸虫病肝损伤相关的重要病原体相关分子模式。此外，大量研究表明，胱天蛋白酶1介导的细胞凋亡参与多种炎症相关疾病的发展。但是，尚不清楚HSC的焦细胞凋亡是否参与SEA介导的肝损伤。

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期刊名称 Filaria Journal
作者
De-Long Kong; Fan-Yun Kong; Xiang-Ye Liu; Chao Yan; Jie Cui; Ren-Xian Tang; Kui-Yang Zheng;
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作者单位

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年(卷),期 2019(12),-1
年度 2019
页码 475
总页数 12
原文格式 PDF
正文语种
中图分类动物医学（兽医学）;
关键词
Schistosomiasis Liver fibrosis Pyroptosis ROS;

机译：血吸虫病;肝纤维化;烧伤;ROS;

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专利

1. Schistosoma japonicum soluble egg antigen inhibits TNF--induced IL-34 expression in hepatic stellate cells [J] . Chen Liuting, Yu Yang, Liu Ertao, Parasitology Research . 2019,第2期

机译：血吸虫瘤可溶性蛋抗原抑制肝星状细胞中的TNF诱导的IL-34表达
2. Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway [J] . Jinling Chen, Jing Pan, Jianxin Wang, Scientific reports. . 2016,第1期

机译：通过STAT3 / P53 / P21途径激活Scistosoma的血吸虫血吸虫蛋瘤中的可溶性蛋诱导衰老
3. Schistosoma japonicum soluble egg antigens induce apoptosis and inhibit activation of hepatic stellate cells: A possible molecular mechanism [J] . DuanY., GuX., ZhuD., International Journal for Parasitology . 2014,第3a4期

机译：日本血吸虫可溶性蛋抗原诱导凋亡并抑制肝星状细胞的激活：一种可能的分子机制
4. Schistosoma Japonicum: Vaccination with Cultured Cells From Juvenile Induced a Partial Immunity to Challege Infections in Mouse Model [C] . L.T. Cai, T.B. Zeng, Q.R. Zeng, International Congress of Parasitology . 2006

机译：日本血吸虫瘤：从少年培养细胞疫苗接种诱导攻击小鼠模型中的攻击感染
5. Exploring the mechanism of cannabidiol-induced death of activated hepatic stellate cells. [D] . Lim, Maribel P. 2011

机译：探索大麻素诱导的活化肝星状细胞死亡的机制。
6. Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway [O] . Yinong Duan, Jing Pan, Jinling Chen, 2016

机译：日本血吸虫的可溶性卵抗原通过激活FoxO3a / SKP2 / P27途径诱导活化的肝星状细胞衰老。
7. Soluble egg antigen of Schistosoma japonicum induces pyroptosis in hepatic stellate cells by modulating ROS production [O] . De-Long Kong, Fan-Yun Kong, Xiang-Ye Liu, 2019

机译：通过调节ROS生产，日本血吸虫血吸虫蛋瘤的可溶性蛋抗原诱导肝脏星状细胞糊化酶
8. Lymphocyte Response in Mice Infected with the Indonesian and Formosan Strains of Schistosoma Japonicum to Concanavalin A, and to Worm and Egg Antigens [R] . Chu, M. H., Cross, J. H. 1980

机译：日本血吸虫印度尼西亚和台湾菌株感染刀豆蛋白a的小鼠和蠕虫和卵抗原的淋巴细胞反应

Soluble egg antigen of Schistosoma japonicum induces pyroptosis in hepatic stellate cells by modulating ROS production

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