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首页> 美国卫生研究院文献>Frontiers in Neuroscience >Research on Assisting Clinicians to Operate rTMS Precisely Based on the Coil Magnetic Field Spatial Distribution With Magnetic Resonance Imaging Navigation
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Research on Assisting Clinicians to Operate rTMS Precisely Based on the Coil Magnetic Field Spatial Distribution With Magnetic Resonance Imaging Navigation

机译：磁共振成像导航基于线圈磁场空间分布的协助临床医生精确操作rTMS的研究

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Objective: To assist clinicians to operate repetitive Transcranial Magnetic Stimulation (rTMS) precisely based on the coil magnetic field spatial distribution with Magnetic Resonance Imaging (MRI) Navigation.Methods: A fast method for calculating electromagnetic fields in layered brain structures in frequency domain was proposed. By approaching Bessel function in different intervals, the integral with a highly oscillatory kernel was transformed into two parts: a definite integral and a weakened oscillatory one. The distribution of induced current density and magnetic field intensity of rTMS stimulation effect on brain was quantitatively calculated, so that clinicians could intuitively grasp the safe range of coil stimulation on the brain. Then, the crucial factor of the stimulation effect of rTMS was determined, and an accurate coil positioning of the rTMS efficiently was completed.Result: The maximal attenuation of induced electric field and magnetic induction intensity was 72.20 and 86.867% at 3 cm away from the skin in the brain layered model. The clinical examination results of electric field intensity distribution, magnetic field intensity distribution, current density distribution, layered brain modeling, and coil location speed in the brain model teaching group were significantly higher than those in the traditional teaching group (P < 0.001).Conclusion: It is suitable for clinicians to quickly complete the precise positioning of rTMS, master the adjustment of coil stimulation therapeutic parameters, and realize the precise positioning operation of rTMS with MRI navigation in intracranial.Clinical Trial registration: Chinese Clinical Trial Registry (ChiCTR1800018616); Registered on 30th September 2018
机译：目的：借助磁共振成像（MRI）导航，可帮助临床医生精确地基于线圈磁场空间分布准确地进行重复性经颅磁刺激（rTMS）。方法：提出了一种计算频域分层脑结构电磁场的方法。通过以不同的间隔接近贝塞尔函数，将具有高度振荡核的积分转换为两部分：确定积分和弱振荡部分。定量计算了rTMS刺激对大脑的感应电流密度和磁场强度的分布，使临床医生可以直观地掌握线圈对大脑刺激的安全范围。然后，确定了rTMS刺激效果的关键因素，并有效地完成了rTMS的精确线圈定位。结果：感应电场和磁感应强度的最大衰减分别为72.20和86.867。 ％在距大脑分层模型中的皮肤3 cm处。脑模型教学组的电场强度分布，磁场强度分布，电流密度分布，分层大脑建模和线圈定位速度的临床检查结果显着高于传统教学组（P <0.001）。 strong>结论：适用于临床医生快速完成rTMS的精确定位，掌握线圈刺激治疗参数的调整，并通过MRI导航实现颅内颅rTMS的精确定位操作。临床试验注册：中国临床试验注册中心（ChiCTR1800018616）； 2018年9月30日注册

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