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首页> 美国卫生研究院文献>Immunology >Cell participation in immune response by immune ribonucleic acid. I. The role of T lymphocytes in immune response by immune RNA against T-dependent antigens.
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Cell participation in immune response by immune ribonucleic acid. I. The role of T lymphocytes in immune response by immune RNA against T-dependent antigens.

机译：细胞参与免疫核糖核酸的免疫反应。 I.T淋巴细胞在针对T依赖性抗原的免疫RNA的免疫应答中的作用。

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T- and B-cell participation in the immune response induced by immune ribonucleic acid (iRNA) preparations against T-dependent antigens was studied using athymic nude, neonatally thymectomized (NT) and cyclophosphamide-treated (CY) mice. The iRNA(T + B) preparations were made from the spleen of BALB/c mice immunized with these antigens. Injection of the iRNA into nude or NT mice caused an increase in the number of specific rosette-forming cells (RFC) and of memory cells capable of responding to secondary stimulus with a small dose of the corresponding antigen. Injection with T-dependent antigens or with iRNA(T + B) did not cause any immune response in CY mice, suggesting depletion of the B-cell function. The iRNA(T) and iRNA(B) were prepared, respectively, from the thymuses of BALB/c mice and from the spleens of nude mice which had been immunized with T-dependent antigens. Injection of nude mice with both iRNA(T) and iRNA(B) caused an increase in the number of specific RFC and the secondary antibody formation response after boosting with a small dose of the corresponding antigen. Injection of iRNA(T) preparation into nude mice could induce the anamnestic response after boosting. However, neither of the iRNA(T) or iRNA(B) preparation could induce in nude mice the proliferation of the number of specific RFC. These results indicate the presence of at least two kinds of iRNA preparations against T-dependent antigens and that the cooperation of iRNA(T) and iRNA(B) was required for the induction of immune response against T-dependent antigens.
机译：使用无胸腺裸鼠，新生儿经胸腺切除术（NT）和环磷酰胺治疗（CY）的小鼠，研究了T细胞和B细胞参与由免疫核糖核酸（iRNA）制剂诱导的针对T依赖性抗原的免疫应答的过程。从用这些抗原免疫的BALB / c小鼠的脾脏制备iRNA（T + B）制剂。将iRNA注射到裸鼠或NT小鼠中导致特异性玫瑰花结形成细胞（RFC）的数量增加，并且能够以小剂量的相应抗原响应次级刺激的记忆细胞数量增加。 T依赖性抗原或iRNA（T + B）注射不会在CY小鼠中引起任何免疫反应，表明B细胞功能耗竭。分别从BALB / c小鼠的胸腺和已用T依赖性抗原免疫的裸鼠脾中制备iRNA（T）和iRNA（B）。注射iRNA（T）和iRNA（B）的裸鼠后，用少量相应抗原加强免疫后，特异性RFC数量和第二抗体形成反应均增加。将iRNA（T）制剂注射到裸鼠体内可增强免疫反应。但是，iRNA（T）或iRNA（B）制剂均不能在裸鼠中诱导特定RFC数量的增殖。这些结果表明存在至少两种针对T依赖性抗原的iRNA制剂，并且诱导i抵抗T依赖性抗原的免疫反应需要iRNA（T）和iRNA（B）的协同作用。

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