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首页> 美国卫生研究院文献>Journal of Anatomy and Physiology >Neuron volume in the ventral horn in Wobbler mouse motoneuron disease: a light microscope stereological study
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Neuron volume in the ventral horn in Wobbler mouse motoneuron disease: a light microscope stereological study

机译：Wobbler小鼠运动神经元疾病的腹角神经元体积：光学显微镜的立体学研究

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Previous pathological reports have indicated that swollen and vacuolated motoneuron cell bodies are the most predominant feature characterising Wobbler mouse motoneuron disease, but there has been little supportive evidence using area measurements. The present study focuses on the possible role of changes in neuronal nuclear and perikaryal volumes in the cervical spinal cord ventral horn, using new and traditional stereological probes which provide unbiased estimates of volume. Semithin sections from the ventral horn of Wobbler mice and age and sex-matched phenotypically normal littermates were examined at 2 ages (young and old). The young Wobbler group had significantly larger volume weighted mean perikaryal volumes compared with age-matched controls, reflecting the presence of large swollen cells characteristic of this group; this situation was reversed in the control group. Number-weighted perikaryal volume estimates in the old Wobbler group were smaller than in age-matched controls. The variation in perikaryal volume was greatest in the young Wobbler group in which the coefficient of variation was 127%. The mean number weighted and volume weighted mean nuclear volumes were significantly smaller in the old Wobbler group compared with age-matched controls and young Wobbler groups. The application of new stereological probes has enabled us to document more precisely these changes in neuronal structure in the Wobbler mutant mouse.
机译：先前的病理学报告表明肿胀和空泡的运动神经元细胞体是Wobbler小鼠运动神经元疾病的最主要特征，但使用面积测量的支持证据很少。本研究着眼于使用新的和传统的立体探头（可提供无偏估计的体积）来改变颈脊髓腹角神经元核和周围神经元体积的可能作用。在2个年龄段（年轻人和老年人）检查了Wobbler小鼠腹角的半薄切片以及年龄和性别匹配的表型正常同窝仔。与年龄相匹配的对照组相比，年轻的Wobbler组的加权平均周周体积明显更大，反映出该组存在特征性的大肿胀细胞。对照组的情况则相反。老Wobbler组的数字加权周界体积估计值小于年龄匹配的对照组。在年轻的Wobbler组中，牙周体积的变化最大，其变异系数为127％。与年龄匹配的对照组和年轻的沃伯勒组相比，老年沃伯勒组的平均数加权和体积加权平均核体积显着较小。新的立体探针的应用使我们能够更精确地记录Wobbler突变小鼠中神经元结构的这些变化。

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