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首页> 美国卫生研究院文献>The Journal of Automatic Chemistry >The Application of Resonance Light Scattering Technique forthe Determination of Tinidazole in Drugs
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The Application of Resonance Light Scattering Technique forthe Determination of Tinidazole in Drugs

机译：共振光散射技术在汽车中的应用药物中替硝唑的含量测定

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摘要

A resonance light scattering technique to determine tinidazole in drugs was developed by tetraphenylboron sodium (TPB). Tinidazole was found to bind B(C6H5)−4 anion and transformed to tinidazole-TPB aggregate which displayed intense resonance scattering light. Effects of factors such as wavelength, acidity, stabilizers, and interferents on the RLS of tinidazole TPB were investigated in detail. The RLS intensity of the tinidazole-TPB suspension was obtained in sulfuric acid solution (pH = 1.44). The resonance scattering light intensity at the maximum RLS peak of 569.5 nm was linear to the concentration of tinidazole in the range of 10.0–30.0 μg mL−1 with a detection limit of 5.0 μg mL−1. Good results were also obtained with the recovery range of 95.13–106.76%. The method was applied to determine tinidazole in injections and tablets, showing high sensitivity and accuracy compared with the high performance liquid chromatography method (HPLC) according to Chinese Pharmacopoeia.
机译：四苯硼酸钠（TPB）开发了一种共振光散射技术，用于测定药物中的替硝唑。替硝唑被发现与B（C6H5）-sup4阴离子结合，并转化为替硝唑-TPB聚集体，显示出强烈的共振散射光。详细研究了波长，酸度，稳定剂和干扰物等因素对替硝唑TPB的RLS的影响。在硫酸溶液（pH = 1.44）中获得了替硝唑-TPB悬浮液的RLS强度。在最大RLS峰569.5 nm处的共振散射光强度与替硝唑的浓度在10.0–30.0μgmL -1 范围内呈线性关系，检出限为5.0μgmL - 1 。回收率达到95.13-106.76％，也取得了良好的结果。该方法用于测定注射剂和片剂中的替硝唑，与根据中国药典的高效液相色谱法（HPLC）相比具有较高的灵敏度和准确性。

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