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首页> 美国卫生研究院文献>Journal of the Boston Society of Medical Sciences >Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes.
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Pristane-induced arthritis in rats: a new model for rheumatoid arthritis with a chronic disease course influenced by both major histocompatibility complex and non-major histocompatibility complex genes.

机译：rist烷诱导的大鼠关节炎：类风湿关节炎的新型模型具有受主要组织相容性复合物和非主要组织相容性复合物基因影响的慢性疾病进程。

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摘要

We present a novel animal model for rheumatoid arthritis induced with a well defined synthetic adjuvant oil, pristane. Two weeks after a single intradermal injection of 150 microliters of pristane, the rats developed severe and chronic arthritis. The inflammation was restricted to the joints and involved pannus formation, major histocompatibility complex (MHC) class II expression, and T lymphocyte infiltration. The initial development as well as the chronic stage of pristane-induced arthritis was ameliorated by treatment with antibodies to the alpha beta-T-cell receptor showing that the disease is T cell dependent. Increased levels of interleukin in serum was seen after pristane injection but not during the chronic stage of arthritis. Joint erosions were accompanied by elevated serum levels of cartilage oligomeric matrix protein. Comparison of MHC congenic LEW strains showed that the severity and chronicity of arthritis varied among the different MHC haplotypes. Rats with RT1f haplotype showed a significantly higher susceptibility to pristane-induced arthritis. A strong influence of non-MHC genes was also suggested by the variability of arthritis susceptibility among different strains with the same MHC haplotype; the most susceptible background was the DA and the least susceptible was the E3. Arthritis induced with a well defined nonimmunogenic adjuvant, with a disease course that closely resembles that of rheumatoid arthritis, makes a suitable animal model for future studies of the pathology and genetics of rheumatoid arthritis.
机译：我们提出了由明确定义的合成佐剂油，synthetic烷诱导的类风湿关节炎的新型动物模型。一次皮内注射150微升p烷后两周，大鼠发展为严重和慢性关节炎。炎症仅限于关节，涉及血管nu形成，主要组织相容性复合体（MHC）II类表达和T淋巴细胞浸润。 rist烷诱导的关节炎的初期发展以及慢性阶段都可以通过用抗α-β-T细胞受体的抗体进行治疗来改善，这表明该疾病是T细胞依赖性的。注射rist烷后可观察到血清中白介素水平升高，但在关节炎的慢性阶段则未见。关节侵蚀伴有血清软骨寡聚基质蛋白水平升高。比较MHC同基因LEW菌株，发现关节炎的严重程度和慢性在不同的MHC单倍型之间有所不同。具有RT1f单倍型的大鼠表现出明显更高的对rist烷诱导的关节炎的敏感性。非MHC基因的强烈影响还被具有相同MHC单倍型的不同菌株之间的关节炎易感性差异所暗示。最易感的背景是DA，最不易感的是E3。用定义明确的非免疫原性佐剂诱导的关节炎，其病程与类风湿关节炎的病程非常相似，为今后对类风湿关节炎的病理学和遗传学研究提供了合适的动物模型。

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