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首页> 美国卫生研究院文献>Journal of the Boston Society of Medical Sciences >CD79 alpha expression in acute myeloid leukemia. High frequency of expression in acute promyelocytic leukemia.
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CD79 alpha expression in acute myeloid leukemia. High frequency of expression in acute promyelocytic leukemia.

机译：CD79α在急性髓细胞性白血病中的表达。急性早幼粒细胞白血病的高表达频率。

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CD79 alpha is a subunit of an intracytoplasmic protein reported to be specific for B lymphocytes, including immature B lineage cells. To evaluate expression of the CD79 alpha antigen in acute myeloid leukemia (AML), we studied forty-eight cases of AML by paraffin section immunohistochemistry. The cases included four MO, nine M1, nine M2, ten M3, ten M4, and six M5 AMLs using criteria of the French-American-British cooperative group. Eleven cases demonstrated cytoplasmic staining for the CD79 alpha antigen, including one M1, nine M3, and one M5 AML. These CD79 alpha-positive cases represented 5% of all non-promyelocytic AMLs and 90% of all acute promyelocytic leukemias studied. All acute promyelocytic leukemias had the characteristic t(15;17)(q24;q21), including two cases of the microgranular variant (M3v). No other B-lineage-associated antigens were found in the CD79 alpha-positive cases, with the exception of a subpopulation of CD19-positive leukemic cells in one patient. The two non-promyelocytic leukemias that expressed CD79 alpha had no evidence of t(15;17) and did not express any additional B-lineage-associated antigens that might suggest a mixed lineage proliferation. This study demonstrates that CD79 alpha expression in acute leukemia is not restricted to B-lineage acute lymphoblastic leukemias and that CD79 alpha expression is frequently associated with t(15;17) acute myeloid leukemia.
机译：CD79 alpha是据报道对B淋巴细胞（包括未成熟的B谱系细胞）具有特异性的胞浆内蛋白的亚基。为了评估CD79α抗原在急性髓细胞性白血病（AML）中的表达，我们通过石蜡切片免疫组织化学研究了48例AML。根据法裔美英合作组织的标准，这些案例包括4个MO，9个M1、9个M2、10个M3、10个M4和6个M5 AML。 11例病例表现出CD79α抗原的细胞质染色，包括1例M1、9例M3和1例M5 AML。这些CD79 alpha阳性病例占研究的所有非早幼粒细胞性AML的5％和所有急性早幼粒细胞性白血病的90％。所有急性早幼粒细胞白血病均具有t（15; 17）（q24; q21）特征，包括两例微颗粒变体（M3v）。除一名患者中CD19阳性白血病细胞亚群外，在CD79α阳性病例中未发现其他B谱系相关抗原。两种表达CD79α的非早幼粒细胞白血病没有t（15; 17）的证据，也没有表达可能暗示混合谱系增殖的任何其他B谱系相关抗原。这项研究表明，急性白血病中的CD79α表达不仅限于B谱系急性淋巴细胞白血病，而且CD79α表达通常与t（15; 17）急性髓细胞白血病相关。

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