首页> 美国卫生研究院文献>Journal of the Boston Society of Medical Sciences >Micromethods for determining activities of energy-producing and non-energy-producing pathways in myocardial tissue.
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Micromethods for determining activities of energy-producing and non-energy-producing pathways in myocardial tissue.

机译:用于确定心肌组织中能量产生和非能量产生途径活动的微方法。

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摘要

The increasingly frequent use of endomyocardial biopsies for diagnosis has provided the opportunity to study myocardial metabolism in patients with cardiac diseases. The authors have tested microassays of the hexose monophosphate shunt, glycolytic pathway, and Krebs cycle and demonstrated that they are easily and reproducibly performed on small pieces of cardiac tissue. They have also used these assays to study myocardial metabolism in 2 patients with endocarditis uncomplicated by congestive heart failure and in 2 patients with congestive heart failure due to idiopathic dilated cardiomyopathy. The ability to quantitate myocardial metabolism in biopsies from patients with a variety of cardiac diseases may enhance our understanding of cardiac pathophysiology.
机译:越来越多地使用心内膜活检进行诊断,为研究心脏病患者的心肌代谢提供了机会。作者测试了己糖一磷酸分流器,糖酵解途径和Krebs循环的微量测定法,并证明了它们在心脏小组织上容易且可重现。他们还使用这些方法研究了2例无充血性心力衰竭并发的心内膜炎患者和2例因特发性扩张型心肌病而充血性心力衰竭的患者的心肌代谢。对患有多种心脏病的患者进行活检时定量心肌代谢的能力可能会增强我们对心脏病理生理学的理解。

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