首页> 美国卫生研究院文献>Journal of the Boston Society of Medical Sciences >Quantitative study on the effect of an ACTH-producing pituitary tumor on the ultrastructure of the mouse adrenal gland.
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Quantitative study on the effect of an ACTH-producing pituitary tumor on the ultrastructure of the mouse adrenal gland.

机译:产生ACTH的垂体瘤对小鼠肾上腺超微结构影响的定量研究。

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摘要

The ultrastructure of the adrenal cortex was studied by quantitative stereologic techniques in LAF1 mice bearing a transplantable, ACTH-secreting pituitary tumor (AtT). The tumor stimulated a significant increase in volume and surface area of smooth endoplasmic reticulum and mitochondrial membranes in all three zones of the adrenal cortex. Concomitantly, plasma corticosterone was increased significantly in tumor-bearing animals. The AtT was an adenoma of the chromophobe type. Continuity of the nuclear membrane with the rough endoplasmic reticulum was readily observed in tumor parenchymal cells.
机译:肾上腺皮质的超微结构通过定量立体技术在携带可移植的分泌ACTH的垂体瘤(AtT)的LAF1小鼠中进行了研究。肿瘤刺激肾上腺皮质所有三个区域的平滑内质网和线粒体膜的体积和表面积显着增加。同时,在荷瘤动物中血浆皮质酮显着增加。 AtT是发色团类型的腺瘤。在肿瘤实质细胞中很容易观察到核膜与粗糙的内质网的连续性。

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