首页> 美国卫生研究院文献>Oxford Open >1534. Polymyxin Antimicrobial Susceptibility (AST) Testing and Breakpoints for P. aeruginosa A. baumannii and Enterobacteriaceae: Recommendations from the United States Committee on Antimicrobial Susceptibility Testing (USCAST)
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1534. Polymyxin Antimicrobial Susceptibility (AST) Testing and Breakpoints for P. aeruginosa A. baumannii and Enterobacteriaceae: Recommendations from the United States Committee on Antimicrobial Susceptibility Testing (USCAST)

机译:1534.铜绿假单胞菌鲍曼不动杆菌和肠杆菌科的多粘菌素药敏试验(AST)和临界点:美国药敏试验委员会(USCAST)的建议

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摘要

BackgroundPolymyxins are important antimicrobial agents for the treatment of infections due to carbapenem-resistant and other multidrug-resistant organisms. Recently, the CLSI and EUCAST have set breakpoints for colistin (EUCAST and CLSI) and polymyxin B (CLSI) with slight differences in recommendations. However, there are issues unique to the polymyxin class that warrant additional guidances. Herein, we assess data related to breakpoint setting and make additional recommendations for polymyxin AST interpretive criteria.
机译:背景多粘菌素是重要的抗微生物剂,可用于治疗因碳青霉烯耐药性和其他多药耐药性生物引起的感染。最近,CLSI和EUCAST已为大肠菌素(EUCAST和CLSI)和多粘菌素B(CLSI)设置了断点,但建议的差异很小。但是,多粘菌素类存在一些独特的问题,需要其他指导。在这里,我们评估与断点设置有关的数据,并为多粘菌素AST解释标准提出其他建议。

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