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首页> 美国卫生研究院文献>PLoS Clinical Trials >Auditory and Cognitive Deficits Associated with Acquired Amusia after Stroke: A Magnetoencephalography and Neuropsychological Follow-Up Study
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Auditory and Cognitive Deficits Associated with Acquired Amusia after Stroke: A Magnetoencephalography and Neuropsychological Follow-Up Study

机译：中风后与获得性失语相关的听觉和认知缺陷：磁脑图学和神经心理学的后续研究

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Acquired amusia is a common disorder after damage to the middle cerebral artery (MCA) territory. However, its neurocognitive mechanisms, especially the relative contribution of perceptual and cognitive factors, are still unclear. We studied cognitive and auditory processing in the amusic brain by performing neuropsychological testing as well as magnetoencephalography (MEG) measurements of frequency and duration discrimination using magnetic mismatch negativity (MMNm) recordings. Fifty-three patients with a left (n = 24) or right (n = 29) hemisphere MCA stroke (MRI verified) were investigated 1 week, 3 months, and 6 months after the stroke. Amusia was evaluated using the Montreal Battery of Evaluation of Amusia (MBEA). We found that amusia caused by right hemisphere damage (RHD), especially to temporal and frontal areas, was more severe than amusia caused by left hemisphere damage (LHD). Furthermore, the severity of amusia was found to correlate with weaker frequency MMNm responses only in amusic RHD patients. Additionally, within the RHD subgroup, the amusic patients who had damage to the auditory cortex (AC) showed worse recovery on the MBEA as well as weaker MMNm responses throughout the 6-month follow-up than the non-amusic patients or the amusic patients without AC damage. Furthermore, the amusic patients both with and without AC damage performed worse than the non-amusic patients on tests of working memory, attention, and cognitive flexibility. These findings suggest domain-general cognitive deficits to be the primary mechanism underlying amusia without AC damage whereas amusia with AC damage is associated with both auditory and cognitive deficits.
机译：获得性失语症是大脑中动脉（MCA）区域受损后的常见疾病。然而，其神经认知机制，特别是知觉和认知因素的相对贡献，仍不清楚。我们通过进行神经心理学测试以及使用磁失配负性（MMNm）记录的频率和持续时间歧视的磁脑电图（MEG）测量来研究音乐大脑中的认知和听觉处理。在卒中后1周，3个月和6个月对53例左半球（n = 24）或右半球（n = 29）MCA脑卒中（经MRI验证）进行了研究。使用蒙特利尔精神病评估电池组（MBEA）对精神错觉进行了评估。我们发现，右半球损伤（RHD）引起的失语症，尤其是颞叶和额叶区域，比左半球损伤（LHD）引起的失语症更为严重。此外，仅在音乐性RHD患者中，发现失乐的严重程度与较弱频率的MMNm反应相关。此外，在RHD亚组中，听觉皮层（AC）受损的音乐患者在整个6个月的随访中，MBEA的恢复较差，MMNm反应较非音乐性患者或音乐性患者弱没有交流电损坏。此外，在工作记忆，注意力和认知柔韧性测试中，有或没有AC损伤的音乐患者的表现都比非音乐患者更差。这些发现表明，一般性认知功能障碍是无AC损伤的失语症的主要机制，而AC损伤的失语症与听觉和认知缺陷均相关。

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