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Endogenous Retinoic Acid Activity in Principal Cells and Intercalated Cells of Mouse Collecting Duct System

机译：小鼠集管系统主细胞和插层细胞中的内源性维甲酸活性

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BackgroundRetinoic acid is the bioactive derivative of vitamin A, which plays an indispensible role in kidney development by activating retinoic acid receptors. Although the location, concentration and roles of endogenous retinoic acid in post-natal kidneys are poorly defined, there is accumulating evidence linking post-natal vitamin A deficiency to impaired renal concentrating and acidifying capacity associated with increased susceptibility to urolithiasis, renal inflammation and scarring. The aim of this study is to examine the presence and the detailed localization of endogenous retinoic acid activity in neonatal, young and adult mouse kidneys, to establish a fundamental ground for further research into potential target genes, as well as physiological and pathophysiological roles of endogenous retinoic acid in the post-natal kidneys.

机译：背景维甲酸是维生素A的生物活性衍生物，它通过激活维甲酸受体在肾脏发育中起着不可或缺的作用。尽管内源性维甲酸在产后肾脏中的位置，浓度和作用尚不明确，但有越来越多的证据表明，出生后维生素A缺乏与肾浓缩和酸化能力受损有关，而后者对尿路结石，肾脏炎症和疤痕的敏感性增加。这项研究的目的是检查新生，年轻和成年小鼠肾脏中内源性维甲酸活性的存在和详细定位，为进一步研究潜在靶基因以及内源性生理和病理生理作用奠定基础产后肾脏中的维甲酸。

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期刊名称 PLoS Clinical Trials
作者
Yuen Fei Wong; Jeffrey B. Kopp; Catherine Roberts; Peter J. Scambler; Yoshifusa Abe; Alexandra C. Rankin; Neelanjana Dutt; Bruce M. Hendry; Qihe Xu;
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年(卷),期 2009(6),2
年度 2009
页码 e16770
总页数 10
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1. Angiotensin II stimulates H-ATPase activity in intercalated cells from isolated mouse connecting tubules and cortical collecting ducts [J] . Wagner C.A., Mohebbi N., Uhlig U., Cellular Physiology and Biochemistry . 2011,第3期

机译：血管紧张素II刺激分离的小鼠连接肾小管和皮层收集管的插层细胞中的H-ATPase活性
2. Angiotensin II Stimulates H+-ATPase Activity in Intercalated Cells from Isolated Mouse Connecting Tubules and Cortical Collecting Ducts [J] . Carsten A. Wagner, Nilufar Mohebbi, Ulrike Uhlig, Cellular Physiology and Biochemistry . 2011,第3期

机译：血管紧张素II刺激从孤立的小鼠连接肾小管和皮层收集管道插入的细胞中的H + -ATPase活性。
3. INTRACELLULAR ACIDIFICATION INDUCES CL/HCO3 EXCHANGE ACTIVITY IN THE BASOLATERAL MEMBRANE OF BETA-INTERCALATED CELLS OF THE RABBIT CORTICAL COLLECTING DUCT [J] . Merot J., Geibel J., Giebisch G. The Journal of Membrane Biology: An International Journal for Studies on the Structure, Function & Genesis of Biomembranes . 1997,第3期

机译：胞内酸化诱导兔间质收集管道的β-插入细胞的基底膜中的CL / HCO3交换活性。
4. Neuralization of mouse embryonic stem cells in alginate hydrogels under retinoic acid and SAG treatment [C] . Delivopoulos Evangelos, Shakesheff Kevin M., Peto Heather Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2015

机译：维甲酸和SAG处理对藻酸盐水凝胶中小鼠胚胎干细胞的神经化作用
5. Differential regulation of stearoyl-CoA desaturase expression and activity by thiazolidinediones, steroid hormones and fatty acid analogs using the mouse 3T3-L1 preadipocyte cell line as model system. [D] . Gomez, Francisco Enrique. 2003

机译：噻唑烷二酮，类固醇激素和脂肪酸类似物使用小鼠3T3-L1前脂肪细胞系作为模型系统，对硬脂酰CoA去饱和酶的表达和活性进行差异调节。
6. Retinoic Acid Receptor-Dependent Cell-Autonomous Endogenous Retinoic Acid Signaling and Its Target Genes in Mouse Collecting Duct Cells [O] . Yuen Fei Wong, Patricia D. Wilson, Robert J. Unwin, -1

机译：视黄酸受体相关的细胞自主内源性维甲酸信号及其靶基因在小鼠集合管细胞
7. Endogenous Retinoic Acid Activity in Principal Cells and Intercalated Cells of Mouse Collecting Duct System [O] . Wong, Yuen Fei, Kopp, Jeffrey B., Roberts, Catherine, 2011

机译：小鼠集管系统主细胞和插层细胞中的内源性维甲酸活性
8. Cellular Regulation of ADP-Ribosylation of Proteins. 4. Conversion of Poly(ADP-Ribose) Polymerase Activity to NAD-Glycohydrolase during Retinoic Acid-Induced Differentiation of HL60 Cells [R] . Kirsten, E., Bauer, P. I., Kun, E. 1991

机译：蛋白质aDp-核糖基化的细胞调节。 4.维甲酸诱导HL60细胞分化过程中聚（aDp-核糖）聚合酶活性转化为NaD-糖水解酶

Endogenous Retinoic Acid Activity in Principal Cells and Intercalated Cells of Mouse Collecting Duct System

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