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首页> 美国卫生研究院文献>PLoS Clinical Trials >Congenital Amusia Persists in the Developing Brain after Daily Music Listening
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Congenital Amusia Persists in the Developing Brain after Daily Music Listening

机译：每天听音乐后，先天性失语症持续存在于发育中的大脑中

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摘要

Congenital amusia is a neurodevelopmental disorder that affects about 3% of the adult population. Adults experiencing this musical disorder in the absence of macroscopically visible brain injury are described as cases of congenital amusia under the assumption that the musical deficits have been present from birth. Here, we show that this disorder can be expressed in the developing brain. We found that (10–13 year-old) children exhibit a marked deficit in the detection of fine-grained pitch differences in both musical and acoustical context in comparison to their normally developing peers comparable in age and general intelligence. This behavioral deficit could be traced down to their abnormal P300 brain responses to the detection of subtle pitch changes. The altered pattern of electrical activity does not seem to arise from an anomalous functioning of the auditory cortex, because all early components of the brain potentials, the N100, the MMN, and the P200 appear normal. Rather, the brain and behavioral measures point to disrupted information propagation from the auditory cortex to other cortical regions. Furthermore, the behavioral and neural manifestations of the disorder remained unchanged after 4 weeks of daily musical listening. These results show that congenital amusia can be detected in childhood despite regular musical exposure and normal intellectual functioning.
机译：先天性失语症是一种神经发育障碍，影响约3％的成年人口。在没有肉眼可见的宏观脑损伤的情况下经历这种音乐障碍的成年人被认为是先天性失语症的病例，其假设是从出生开始就存在音乐缺陷。在这里，我们证明了这种疾病可以在发育中的大脑中表达。我们发现（10-13岁的儿童）与正常年龄的同龄人和一般智力相比，他们在音乐和听觉方面都无法发现细微的音高差异。这种行为缺陷可以追溯到他们对检测到细微音调变化的异常P300脑反应。电活动模式的改变似乎不是由听觉皮层的异常功能引起的，因为脑电势的所有早期组成部分，N100，MMN和P200看起来都是正常的。相反，大脑和行为措施指向从听觉皮层到其他皮层区域的信息传播受到干扰。此外，在每天听音乐4周后，该疾病的行为和神经表现仍未改变。这些结果表明，尽管有规律的音乐暴露和正常的智力功能，但仍可在儿童期发现先天性失语症。

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