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Impact of Large Aggregated Uricases and PEG Diol on Accelerated Blood Clearance of PEGylated Canine Uricase

机译：大量的尿酸酶和PEG二醇对PEG化犬尿酸酶加速血液清除的影响

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摘要

BackgroundUricase has proven therapeutic value in treating hyperuricemia but sufficient reduction of its immunogenicity may be the largest obstacle to its chronic use. In this study, canine uricase was modified with 5 kDa mPEG-SPA and the impact of large aggregated uricases and cross-linked conjugates induced by difunctional PEG diol on immunogenicity was investigated.

机译：背景尿酸酶已被证明可治疗高尿酸血症，但其免疫原性的充分降低可能是其长期使用的最大障碍。在这项研究中，用5 kDa mPEG-SPA修饰了犬尿酸酶，并研究了双酶PEG二醇诱导的大分子尿酸酶和交联结合物对免疫原性的影响。

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期刊名称 PLoS Clinical Trials
作者
Chun Zhang; Kai Fan; Xuefeng Ma; Dongzhi Wei;
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年(卷),期 2009(7),6
年度 2009
页码 e39659
总页数 11
原文格式 PDF
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专利

1. A hydroxyl PEG version of PEGylated liposomes and its impact on anti-PEG IgM induction and on the accelerated clearance of PEGylated liposomes [J] . Shimizu Taro, Abu Lila Amr S., Fujita Risako, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2018,第期

机译：羟吡格吡酰型脂质化脂质体及其对抗PEG IgM诱导的影响及其加速脂质化脂质体的促进
2. Hepatosplenic phagocytic cells indirectly contribute to anti -PEG IgM production in the accelerated blood clearance (ABC) phenomenon against PEGylated liposomes: Appearance of an unexplained mechanism in the ABC phenomenon [J] . El Sayed Marwa Mohamed, Takata Haruka, Shimizu Taro, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2020,第1期

机译：肝瓣蜂鸣细胞间接有助于抗-peg IgM生产在加速血液清除（ABC）现象中对乙二醇化脂质体的现象：ABC现象中未解释的机制的出现
3. Exploring the relationship between anti-PEG IgM behaviors and PEGylated nanoparticles and its significance for accelerated blood clearance [J] . Shiraishi Kouichi, Kawano Kumi, Maitani Yoshie, Journal of Controlled Release: Official Journal of the Controlled Release Society . 2016,第Null期

机译：探索抗PEG IgM行为与PEG化纳米颗粒之间的关系及其对加速血液清除的意义
4. Accelerated clearance of ultrasound contrast agents containing polyethylene glycol (PEG) is associated with a PEG-specific immune response [C] . Samantha M. Fix, A. Gloria Nyankima, Morgan D. McSweeney, IEEE International Ultrasonics Symposium . 2017

机译：包含聚乙二醇（PEG）的超声造影剂的加速清除与PEG特异性免疫反应有关
5. Evaluating the impacts of accelerated incident clearance tools and strategies by harnessing the power of microscopic traffic simulation. [D] . Fries, Ryan. 2007

机译：通过利用微观交通仿真的力量来评估加速事件清除工具和策略的影响。
6. Economic analysis of uricase production under uncertainty: Contrast of chromatographic purification and aqueous two‐phase extraction (with and without PEG recycle) [O] . Mario A. Torres‐Acosta, José M. Aguilar‐Yáñez, Marco Rito‐Palomares, -1

机译：不确定情况下尿酸酶生产的经济分析：色谱纯化和水两相萃取（有和没有PEG循环）的对比
7. Impact of Large Aggregated Uricases and PEG Diol on Accelerated Blood Clearance of PEGylated Canine Uricase [O] . Zhang, Chun, Fan, Kai, Ma, Xuefeng, 2012

机译：大量的尿酸酶和PEG二醇对PEG化犬尿酸酶加速血液清除的影响

Impact of Large Aggregated Uricases and PEG Diol on Accelerated Blood Clearance of PEGylated Canine Uricase

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