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首页> 美国卫生研究院文献>PLoS Clinical Trials >Increased Carotid Intima-Media Thickness and Reduced Distensibility in Human Class III Obesity: Independent and Differential Influences of Adiposity and Blood Pressure on the Vasculature
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Increased Carotid Intima-Media Thickness and Reduced Distensibility in Human Class III Obesity: Independent and Differential Influences of Adiposity and Blood Pressure on the Vasculature

机译：在人类三级肥胖中颈动脉内膜中层厚度增加和扩张性降低：肥胖和血压对脉管系统的独立和差异影响

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Carotid intima-media-thickness (cIMT) and carotid distensibility (distensibility), structural and functional properties of carotid arteries respectively, are early markers, as well as strong predictors of cardiovascular disease (CVD). The characteristic of these two parameters in individuals with BMI>40.0 kg/m2 (Class III obesity), however, are largely unknown. The present study was designed to document cIMT and distensibility in this population and to relate these to other factors with established association with CVD in obesity. The study included 96 subjects (65 with BMI>40.0 kg/m2 and 31, age- and gender-matched, with BMI of 18.5 to 30.0 kg/m2). cIMT and distensibility were measured by non-invasive high resolution ultrasonography, circulatory CD133+/KDR+ angiogenic cells and endothelial microparticles (EMP) by flow cytometry, and plasma levels of adipokines, growth factors and cytokines by Luminex immunoassay kits. The study results demonstrated increased cIMT (0.62±0.11 mm vs. 0.54±0.08 mm, P = 0.0002) and reduced distensibility (22.52±10.79 10−3kpa−1 vs. 29.91±12.37 10−3kpa−1, P<0.05) in individuals with BMI>40.0 kg/m2. Both cIMT and distensibility were significantly associated with traditional CVD risk factors, adiposity/adipokines and inflammatory markers but had no association with circulating angiogenic cells. We also demonstrated, for the first time, elevated plasma EMP levels in individuals with BMI>40.0 kg/m2. In conclusion, cIMT is increased and distensibility reduced in Class III obesity with the changes predominantly related to conventional CVD risk factors present in this condition, demonstrating that both cIMT and distensibility remain as CVD markers in Class III obesity.
机译：颈动脉内膜中层厚度（cIMT）和颈动脉扩张性（distensibility），颈动脉的结构和功能特性分别是心血管疾病（CVD）的早期标记和强力预测指标。然而，对于BMI> 40.0 kg / m 2 （III级肥胖）的人，这两个参数的特征尚不清楚。本研究旨在记录该人群中的cIMT和扩张性，并将其与肥胖中与CVD建立关联的其他因素相关联。该研究包括96名受试者（65名BMI> 40.0 kg / m 2 和31名年龄和性别匹配的受试者，BMI为18.5至30.0 kg / m 2 ） 。通过流式细胞术，无创高分辨率超声检查，循环中的CD133 + / KDR + 血管生成细胞和内皮微粒（EMP）来测量cIMT和扩张性，并测定血浆脂联素的水平，Luminex免疫分析试剂盒检测生长因子和细胞因子。研究结果表明cIMT增加了（0.62±0.11 mm vs.0.54±0.08 mm，P = 0.0002）并降低了可扩展性（22.52±10.79 10 -3 kpa -1 vs 。29.91±12.37 10 −3 kpa -1 ，P <0.05），体重指数> 40.0 kg / m 2 。 cIMT和扩张性均与传统的CVD危险因素，肥胖/脂肪因子和炎性标志物显着相关，但与循环血管生成细胞无关。我们还首次证明BMI> 40.0 kg / m 2 的个体血浆EMP水平升高。总之，在这种情况下，cIMT升高且可扩张性降低，主要与常规CVD危险因素有关，表明cIMT和可扩张性均作为III类肥胖症的CVD指标。

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