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首页> 美国卫生研究院文献>PLoS Clinical Trials >Hypnotizability and Placebo Analgesia in Waking and Hypnosis as Modulators of Auditory Startle Responses in Healthy Women: An ERP Study
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Hypnotizability and Placebo Analgesia in Waking and Hypnosis as Modulators of Auditory Startle Responses in Healthy Women: An ERP Study

机译：催眠和催眠中的催眠作用和安慰剂镇痛作为健康女性听觉惊吓反应的调节剂：一项ERP研究

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We evaluated the influence of hypnotizability, pain expectation, placebo analgesia in waking and hypnosis on tonic pain relief. We also investigated how placebo analgesia affects somatic responses (eye blink) and N100 and P200 waves of event-related potentials (ERPs) elicited by auditory startle probes. Although expectation plays an important role in placebo and hypnotic analgesia, the neural mechanisms underlying these treatments are still poorly understood. We used the cold cup test (CCT) to induce tonic pain in 53 healthy women. Placebo analgesia was initially produced by manipulation, in which the intensity of pain induced by the CCT was surreptitiously reduced after the administration of a sham analgesic cream. Participants were then tested in waking and hypnosis under three treatments: (1) resting (Baseline); (2) CCT-alone (Pain); and (3) CCT plus placebo cream for pain relief (Placebo). For each painful treatment, we assessed pain and distress ratings, eye blink responses, N100 and P200 amplitudes. We used LORETA analysis of N100 and P200 waves, as elicited by auditory startle, to identify cortical regions sensitive to pain reduction through placebo and hypnotic analgesia. Higher pain expectation was associated with higher pain reductions. In highly hypnotizable participants placebo treatment produced significant reductions of pain and distress perception in both waking and hypnosis condition. P200 wave, during placebo analgesia, was larger in the frontal left hemisphere while placebo analgesia, during hypnosis, involved the activity of the left hemisphere including the occipital region. These findings demonstrate that hypnosis and placebo analgesia are different processes of top-down regulation. Pain reduction was associated with larger EMG startle amplitudes, N100 and P200 responses, and enhanced activity within the frontal, parietal, and anterior and posterior cingulate gyres. LORETA results showed that placebo analgesia modulated pain-responsive areas known to reflect the ongoing pain experience.
机译：我们评估了催眠，催眠中的催眠作用，预期疼痛，安慰剂镇痛和催眠作用对缓解疼痛的影响。我们还研究了安慰剂镇痛如何影响躯体反应（眨眼）以及听觉惊吓探针引起的事件相关电位（ERP）的N100和P200波。尽管期望在安慰剂和催眠镇痛中起着重要的作用，但对这些疗法的神经机制仍知之甚少。我们使用冷杯测试（CCT）诱发了53名健康女性的强直性疼痛。安慰剂镇痛最初是通过操作产生的，在这种情况下，使用伪镇痛膏后，CCT引起的疼痛强度会秘密降低。然后在三种治疗下测试参与者的苏醒和催眠状态：（1）休息（基线）； （2）仅CCT（疼痛）； （3）CCT加安慰剂乳膏可缓解疼痛（安慰剂）。对于每种痛苦的治疗，我们评估了疼痛和痛苦等级，眨眼反应，N100和P200振幅。根据听觉惊吓，我们使用LORETA对N100和P200波的分析来确定对安慰剂和催眠镇痛减轻疼痛敏感的皮质区域。较高的疼痛期望与较高的疼痛减轻相关。在高度催眠状态的参与者中，安慰剂治疗可在苏醒和催眠状态下显着减轻疼痛和痛苦感。在安慰剂镇痛期间，P200波在额叶左半球较大，而在催眠期间，安慰剂镇痛涉及包括枕骨区在内的左半球活动。这些发现表明，催眠和安慰剂镇痛是自上而下调节的不同过程。疼痛减轻与较大的EMG惊吓幅度，N100和P200反应以及额叶，顶叶以及前扣带回和后扣带回内的活动增强相关。 LORETA结果表明，安慰剂镇痛可调节疼痛反应区域，已知该区域可反映正在进行的疼痛经历。

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