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首页> 美国卫生研究院文献>PLoS Clinical Trials >Evaluation of Anticancer and Antioxidant Activity of a Commercially Available CO2 Supercritical Extract of Old Man’s Beard (Usnea barbata)
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Evaluation of Anticancer and Antioxidant Activity of a Commercially Available CO2 Supercritical Extract of Old Man’s Beard (Usnea barbata)

机译：商用胡须的超临界CO2超临界提取物（Usnea barbata）的抗癌和抗氧化活性评估

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摘要

There is a worldwide ongoing investigation for novel natural constituents with cytotoxic and antioxidant properties. The aim of this study was to investigate chemical profile and stated biological activities of the supercritical CO2 extract (SCE) of old man’s beard compared to the extracts obtained using the conventional techniques (Soxhlet extracts and macerate). The most abundant compound identified was usnic acid, which content was inversely proportional to the polarity of the solvent used and was the highest in the SCE, which was the sample revealing the highest cytotoxic activity in tested tumor cell lines (B16 mouse melanoma and C6 rat glioma), with lower IC50 values compared to pure usnic acid. Further investigations suggested both SCE and usnic acid to induce apoptosis and/or autophagy in B16 and C6, indicating higher cytotoxicity of SCE to be related to the higher degree of ROS production. A good correlation of usnic acid content in the extracts and their antioxidant capacity was established, extricating SCE as the most active one. Presented results support further investigations of SCE of old man’s beard as a prospective therapeutic agent with potential relevance in the treatment of cancer and/or in oxidative stress-mediated conditions.
机译：全球范围内正在进行对具有细胞毒性和抗氧化特性的新型天然成分的研究。这项研究的目的是研究老年人胡须的超临界CO2提取物（SCE）与使用常规技术获得的提取物（索氏提取物和浸软胶）相比的化学特征和生物学活性。鉴定出的最丰富的化合物是松萝酸，其含量与所用溶剂的极性成反比，并且在SCE中含量最高，该样品显示出在测试的肿瘤细胞系（B16小鼠黑素瘤和C6大鼠）中具有最高的细胞毒活性胶质瘤），其IC50值低于纯松萝酸。进一步的研究表明，SCE和松萝酸都可以诱导B16和C6中的细胞凋亡和/或自噬，表明SCE更高的细胞毒性与ROS产生的程度更高有关。建立了提取物中的松萝酸含量与其抗氧化能力的良好相关性，使SCE成为最活跃的一种。提出的结果支持对老人胡须的SCE进行进一步的研究，作为一种前瞻性治疗剂，在治疗癌症和/或氧化应激介导的疾病方面具有潜在的相关性。

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