• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>PLoS Clinical Trials >Off-label use of ceftiofur in one-day chicks triggers a short-term increase of ESBL-producing E. coli in the gut
【2h】

Off-label use of ceftiofur in one-day chicks triggers a short-term increase of ESBL-producing E. coli in the gut

机译：在一天的雏鸡中乱用头孢噻呋会触发肠道中产生ESBL的大肠杆菌的短期增加

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This trial was designed to evaluate the off-label use of ceftiofur with Marek’s vaccine in one-day-old broiler chicks, a prophylactic treatment that has been done in some commercial hatcheries, on the emergence of extended-spectrum beta-lactamase producing Escherichia coli (ESBL-E. coli). A total of 168 chicks (Cobb500®) were used in a completely randomized design. Birds were assigned to two treatments (Marek’s vaccine plus saline vs Marek’s vaccine plus ceftiofur) and six repetitions, with 14 animals each. Cloacal swabs were collected from 1 to 14 days post-hatch. The majority (86%; p<0.0001) of the ESBL-producing isolates harboring blaCTX-M and blaSHV genes originated from animals receiving the antimicrobial. None of the isolates were positive for plasmid-mediated AmpC betalactamase genes (blaACC, blaCMY-2, blaDHA, blaFOX, blaMOX and blaMIR). These findings indicate that the off-label use of ceftiofur with Marek’s vaccine is associated with the short-term increase in ESBL-producing Escherichia coli in the gut of chicks.
机译：该试验旨在评估在一天大的肉鸡雏鸡中使用头孢噻呋和马立克氏疫苗的标签外使用情况，这是在一些商业孵化场中对产生广谱β-内酰胺酶的大肠杆菌的出现进行的预防性治疗。 （ESBL-E.coli）。完全随机设计总共使用了168只小鸡（Cobb500 ®）。鸟类被指定为两种处理方法（Marek的疫苗加生理盐水vs Marek的疫苗加头孢噻呋）和六次重复，每组14只。孵化后1到14天收集泄殖腔拭子。带有blaCTX-M和blaSHV基因的大多数ESBL分离株产生于ESBL，这些分离株源自接受抗微生物剂的动物。分离物均未对质粒介导的AmpCβ-内酰胺酶基因（blaACC，blaCMY-2，blaDHA，blaFOX，blaMOX和blaMIR）呈阳性。这些发现表明，马立克氏疫苗不合用头孢噻呋与雏鸡肠道中产生ESBL的大肠杆菌的短期增加有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号