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Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial

机译：研究性季节性流感血凝素DNA疫苗以及三价灭活疫苗在健康成年人体内皮内或肌肉内给药的安全性和免疫原性：一项开放标签的随机1期临床试验

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BackgroundSeasonal influenza results in significant morbidity and mortality worldwide, but the currently licensed inactivated vaccines generally have low vaccine efficacies and could be improved. In this phase 1 clinical trial, we compared seasonal influenza vaccine regimens with different priming strategies, prime-boost intervals, and administration routes to determine the impact of these variables on the resulting antibody response.

机译：背景季节性流感在全世界范围内导致大量的发病率和死亡率，但是目前已获许可的灭活疫苗通常具有较低的疫苗功效并且可以加以改善。在此1期临床试验中，我们将季节性流感疫苗接种方案与不同的引发策略，引发-加强间隔和给药途径进行了比较，以确定这些变量对所得抗体反应的影响。

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期刊名称 PLoS Clinical Trials
作者
Cristina Carter; Katherine V. Houser; Galina V. Yamshchikov; Abbie R. Bellamy; Jeanine May; Mary E. Enama; Uzma Sarwar; Brenda Larkin; Robert T. Bailer; Richard Koup; Grace L. Chen; Shital M. Patel; Patricia Winokur; Robert Belshe; Cornelia L. Dekker; Barney S. Graham; Julie E. Ledgerwood;
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年(卷),期 2012(14),9
年度 2012
页码 e0222178
总页数 18
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1. Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial [J] . Cristina Carter, Katherine V. Houser, Galina V. Yamshchikov, PLoS One . 2019,第9期

机译：调查季节性流感血凝素DNA疫苗的安全性和免疫原性，然后是在健康成人的皮内或肌肉内施用的三价灭活疫苗：开放式随机阶段1临床试验
2. Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a phase I randomized clinical trial in healthy Serbian adults [J] . Stevanovic Goran, Lavadinovic Lidija, Vignjevic Svetlana Filipovic, Human vaccines & immunotherapeutics. . 2018,第3期

机译：季节性三价灭活分裂流感疫苗的安全性和免疫原性：I阶段在健康塞尔维亚成人中随机化临床试验
3. Immunogenicity, reactogenicity, and safety of inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine in healthy adults aged = 18 years: A phase III, randomized trial [J] . Tinoco Juan Carlos, Pavia-Ruz Noris, Cruz-Valdez Aurelio, Vaccine . 2014,第13期

机译：≥18岁健康成年人体内灭活的四价流感疫苗候选物与灭活的三价流感疫苗的免疫原性，反应原性和安全性：III期随机试验
4. A double-blind, randomized phase II trial of thesafety and immunogenicity of 26-valent group A streptococcus vaccine in healthy adults [C] . Shelly A. McNeil, Scott A. Halperin, Joanne M. Langley, Lancefield International Symposium on Streptococci and Streptococcal Diseases . 2006

机译：一种双盲，随机期II试验，对健康成人的26岁的26岁群体的疫苗疫苗
5. Safety and immunogenicity of a seasonal trivalent inactivated split influenza vaccine: a double blind phase III randomized clinical trial in healthy Serbian adults [O] . Goran Stevanovic, Aleksandar Obradovic, Snezana Ristic, 2020

机译：季节性三价灭活流感分裂疫苗的安全性和免疫原性：健康塞尔维亚成年人的双盲III期随机临床试验
6. Immunogenicity, reactogenicity, and safety of inactivated quadrivalent influenza vaccine candidate versus inactivated trivalent influenza vaccine in healthy adults aged ≥18 years: A phase III, randomized trial [O] . Tinoco Juan Carlos, Pavia-Ruz Noris, Cruz-Valdez Aurelio, 2014

机译：≥18岁健康成年人中灭活的四价流感疫苗候选物与灭活的三价流感疫苗候选物的免疫原性，反应原性和安全性：III期随机试验

Safety and immunogenicity of investigational seasonal influenza hemagglutinin DNA vaccine followed by trivalent inactivated vaccine administered intradermally or intramuscularly in healthy adults: An open-label randomized phase 1 clinical trial

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