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Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

机译：通过复制和非复制载体在植物中快速瞬时生产可产生高质量的功能性抗HIV抗体

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BackgroundThe capacity of plants and plant cells to produce large amounts of recombinant protein has been well established. Due to advantages in terms of speed and yield, attention has recently turned towards the use of transient expression systems, including viral vectors, to produce proteins of pharmaceutical interest in plants. However, the effects of such high level expression from viral vectors and concomitant effects on host cells may affect the quality of the recombinant product.

机译：背景技术植物和植物细胞产生大量重组蛋白的能力已得到充分确立。由于在速度和产量方面的优势，近来注意力转向使用瞬时表达系统，包括病毒载体，来在植物中产生药学上感兴趣的蛋白质。但是，病毒载体的这种高水平表达的作用以及对宿主细胞的伴随作用可能影响重组产物的质量。

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期刊名称 PLoS Clinical Trials
作者
Frank Sainsbury; Markus Sack; Johannes Stadlmann; Heribert Quendler; Rainer Fischer; George P. Lomonossoff;
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年(卷),期 2010(5),11
年度 2010
页码 e13976
总页数 9
原文格式 PDF
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专利

1. Early life vaccination: Generation of adult-quality memory CD8+ T cells in infant mice using non-replicating adenoviral vectors [J] . Loulieta Nazerai, Maria R. Bassi, Ida E. M. Uddback, Scientific reports. . 2016,第1期

机译：生命早期疫苗接种：使用非复制型腺病毒载体在婴儿小鼠中生成成人质量的记忆CD8 + T细胞
2. Rapid high-yield expression of full-size IgG antibodies in plants coinfected with noncompeting viral vectors [J] . Anatoli Giritch, Sylvestre Marillonnet, Carola Engler, Proceedings of the National Academy of Sciences of the United States of America . 2006,第40期

机译：非竞争性病毒载体共感染植物中全尺寸IgG抗体的快速高产量表达
3. Replicating and non-replicating viral vectors for vaccine development. [J] . Robert-Guroff M Current opinion in biotechnology . 2007,第6期

机译：用于疫苗开发的复制型和非复制型病毒载体。
4. Mammalian In Vitro Translation (Cell-Free) Systems for Rapid and High-Yield Expression of Functional Proteins Including Antibodies [C] . Penny Jensen, Krishna Vattem, Justin Saul, PEGS . 2015

机译：哺乳动物体外翻译（无细胞）系统，用于快速和高产功能蛋白质表达，包括抗体
5. New viral vectors for the expression of antigens and antibodies in plants [D] . Liu, Zun 2009

机译：用于在植物中表达抗原和抗体的新型病毒载体
6. Rapid High-Level Production of Functional HIV Broadly Neutralizing Monoclonal Antibodies in Transient Plant Expression Systems [O] . Yvonne Rosenberg, Markus Sack, David Montefiori, -1

机译：在瞬时植物表达系统中快速高水平生产功能性HIV广泛中和的单克隆抗体
7. Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody [O] . Sainsbury, Frank, Sack, Markus, Stadlmann, Johannes, 2010

机译：通过复制和非复制载体在植物中快速瞬时生产可产生高质量的功能性抗HIV抗体

Rapid Transient Production in Plants by Replicating and Non-Replicating Vectors Yields High Quality Functional Anti-HIV Antibody

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