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Measurement of Pulmonary Flow Reserve and Pulmonary Index of Microcirculatory Resistance for Detection of Pulmonary Microvascular Obstruction

机译:检测肺血流储备量和微循环阻力肺指数以检测肺微血管阻塞

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摘要

BackgroundThe pulmonary microcirculation is the chief regulatory site for resistance in the pulmonary circuit. Despite pulmonary microvascular dysfunction being implicated in the pathogenesis of several pulmonary vascular conditions, there are currently no techniques for the specific assessment of pulmonary microvascular integrity in humans. Peak hyperemic flow assessment using thermodilution-derived mean transit-time (Tmn) facilitate accurate coronary microcirculatory evaluation, but remain unvalidated in the lung circulation. Using a high primate model, we aimed to explore the use of Tmn as a surrogate of pulmonary blood flow for the purpose of measuring the novel indices Pulmonary Flow Reserve [PFR = (maximum hyperemic)/(basal flow)] and Pulmonary Index of Microcirculatory Resistance [PIMR = (maximum hyperemic distal pulmonary artery pressure)×(maximum hyperemic Tmn)]. Ultimately, we aimed to investigate the effect of progressive pulmonary microvascular obstruction on PFR and PIMR.
机译:背景肺微循环是肺回路阻力的主要调节部位。尽管肺微血管功能障碍与几种肺血管疾病的发病机理有关,但目前尚无用于特异性评估人肺微血管完整性的技术。使用热稀释衍生的平均通过时间(Tmn)进行的峰值充血流量评估有助于准确的冠状动脉微循环评估,但在肺循环中仍然无效。使用高灵长类动物模型,我们旨在探索使用Tmn作为肺血流替代指标,以测量新指标肺流量储备[PFR =(最大充血)/(基础血流量)]和微循环系统的肺指数阻力[PIMR =(最大充血远端肺动脉压)×(最大充血Tmn)]。最终,我们旨在研究进行性肺微血管阻塞对PFR和PIMR的影响。

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