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首页> 美国卫生研究院文献>Society for Endocrinology Open Access >Mating induces the expression of immune- and pH-regulatory genes in the utero-vaginal junction containing mucosal sperm-storage tubuli of hens
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Mating induces the expression of immune- and pH-regulatory genes in the utero-vaginal junction containing mucosal sperm-storage tubuli of hens

机译：交配诱导免疫和pH调节基因在包含粘膜精子存储母鸡的子宫-阴道交界处的表达

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摘要

The female chicken, as with other species with internal fertilization, can tolerate the presence of spermatozoa within specialized sperm-storage tubuli (SST) located in the mucosa of the utero-vaginal junction (UVJ) for days or weeks, without eliciting an immune response. To determine if the oviduct alters its gene expression in response to sperm entry, segments from the oviduct (UVJ, uterus, isthmus, magnum and infundibulum) of mated and unmated (control) hens, derived from an advanced inter-cross line between Red Junglefowl and White Leghorn, were explored 24 h after mating using cDNA microarray analysis. Mating shifted the expression of fifteen genes in the UVJ (53.33% immune-modulatory and 20.00% pH-regulatory) and seven genes in the uterus, none of the genes in the latter segment overlapping the former (with the differentially expressed genes themselves being less related to immune-modulatory function). The other oviductal segments did not show any significant changes. These findings suggest sperm deposition causes a shift in expression in the UVJ (containing mucosal SST) and the uterus for genes involved in immune-modulatory and pH-regulatory functions, both relevant for sperm survival in the hen's oviduct.
机译：雌性鸡与其他内部受精的鸡一样，可以耐受位于子宫-阴道交界处（UVJ）粘膜的专门的精子储存小管（SST）内的精子存在数天或数周，而不会引起免疫反应。为了确定输卵管是否响应精子进入而改变其基因表达，可从红色和无交配的（对照）母鸡的输卵管（UVJ，子宫，地峡，大瓶盖和漏斗）中分离出一段，这些段取自红色丛林鸟之间的高级交叉线交配后24 h，使用cDNA微阵列分析法探索了Long和White Leghorn。交配改变了UVJ中的15个基因（53.33％的免疫调节和20.00％的pH调节）的表达以及子宫中的7个基因的表达，后者中的任何一个基因都与前者不重叠（差异表达的基因本身较少）与免疫调节功能有关）。其他输卵管段未显示任何明显变化。这些发现表明，精子沉积会导致涉及免疫调节和pH调节功能的基因在UVJ（含黏膜SST）和子宫中的表达发生变化，这两者都与母鸡输卵管中的精子存活有关。

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