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首页> 美国卫生研究院文献>Springer Open Choice >Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon
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Target identification for the diagnosis and intervention of vulnerable atherosclerotic plaques beyond 18F-fluorodeoxyglucose positron emission tomography imaging: promising tracers on the horizon

机译：用于18F-氟脱氧葡萄糖正电子发射断层扫描成像以外的易损动脉粥样硬化斑块的诊断和干预的目标识别：即将到来的示踪剂

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Cardiovascular disease is the major cause of morbidity and mortality in developed countries and atherosclerosis is the major cause of cardiovascular disease. Atherosclerotic lesions obstruct blood flow in the arterial vessel wall and can rupture leading to the formation of occlusive thrombi. Conventional diagnostic tools are still of limited value for identifying the vulnerable arterial plaque and for predicting its risk of rupture and of releasing thromboembolic material. Knowledge of the molecular and biological processes implicated in the process of atherosclerosis will advance the development of imaging probes to differentiate the vulnerable plaque. The development of imaging probes with high sensitivity and specificity in identifying high-risk atherosclerotic vessel wall changes and plaques is crucial for improving knowledge-based decisions and tailored individual interventions. Arterial PET imaging with 18F-FDG has shown promising results in identifying inflammatory vessel wall changes in numerous studies and clinical trials. However, due to its limited specificity in general and its intense physiological uptake in the left ventricular myocardium that impair imaging of the coronary arteries, different PET tracers for the molecular imaging of atherosclerosis have been evaluated. This review describes biological, chemical and medical expertise supporting a translational approach that will enable the development of new or the evaluation of existing PET tracers for the identification of vulnerable atherosclerotic plaques for better risk prediction and benefit to patients.
机译：在发达国家，心血管疾病是发病率和死亡率的主要原因，而动脉粥样硬化是心血管疾病的主要原因。动脉粥样硬化病变会阻塞动脉血管壁的血流，并可能破裂导致闭塞性血栓形成。常规的诊断工具在识别脆弱的动脉斑块以及预测其破裂和释放血栓栓塞物质的风险方面仍然具有有限的价值。对动脉粥样硬化过程中涉及的分子和生物学过程的了解将促进成像探针的发展，以区分易损斑块。在识别高风险的动脉粥样硬化血管壁的变化和斑块方面，开发具有高灵敏度和特异性的成像探针对于改善基于知识的决策和量身定制的个体干预至关重要。在许多研究和临床试验中，使用 18 F-FDG进行的动脉PET成像在确定炎症性血管壁变化方面显示出令人鼓舞的结果。然而，由于其总体上有限的特异性以及其在左心室心肌中的强烈生理摄取而损害冠状动脉的成像，因此已经评估了用于动脉粥样硬化分子成像的不同PET示踪剂。这篇综述描述了支持转化方法的生物学，化学和医学专业知识，这将有助于开发新的或评估现有的PET示踪剂，以鉴定易损的动脉粥样硬化斑块，从而更好地预测风险并使患者受益。

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