首页> 美国卫生研究院文献>Springer Open Choice >Potential application of cell reprogramming techniques for cancer research
【2h】

Potential application of cell reprogramming techniques for cancer research

机译:细胞重编程技术在癌症研究中的潜在应用

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

The ability to control the transition from an undifferentiated stem cell to a specific cell fate is one of the key techniques that are required for the application of interventional technologies to regenerative medicine and the treatment of tumors and metastases and of neurodegenerative diseases. Reprogramming technologies, which include somatic cell nuclear transfer, induced pluripotent stem cells, and the direct reprogramming of specific cell lineages, have the potential to alter cell plasticity in translational medicine for cancer treatment. The characterization of cancer stem cells (CSCs), the identification of oncogene and tumor suppressor genes for CSCs, and the epigenetic study of CSCs and their microenvironments are important topics. This review summarizes the application of cell reprogramming technologies to cancer modeling and treatment and discusses possible obstacles, such as genetic and epigenetic alterations in cancer cells, as well as the strategies that can be used to overcome these obstacles to cancer research.
机译:控制从未分化干细胞向特定细胞命运转变的能力是将介入技术应用于再生医学以及治疗肿瘤和转移瘤以及神经退行性疾病所需的关键技术之一。重编程技术,包括体细胞核转移,诱导性多能干细胞以及特定细胞谱系的直接重编程,有可能改变用于癌症治疗的转化医学中的细胞可塑性。癌症干细胞(CSCs)的表征,CSCs的癌基因和抑癌基因的鉴定以及CSCs及其微环境的表观遗传研究是重要的主题。这篇综述总结了细胞重编程技术在癌症建模和治疗中的应用,并讨论了可能的障碍,例如癌细胞中的遗传和表观遗传学改变,以及可以用来克服这些癌症研究障碍的策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号