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首页> 美国卫生研究院文献>Springer Open Choice >Leisure-time physical activity among adolescents and subsequent use of antidepressant and hypnotic drugs: a prospective register linkage study
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Leisure-time physical activity among adolescents and subsequent use of antidepressant and hypnotic drugs: a prospective register linkage study

机译：青少年的休闲运动以及随后使用抗抑郁药和催眠药的前瞻性注册连锁研究

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In this prospective study, the association between physical activity and subsequent use of antidepressant and hypnotic drug use in adolescents aged 15–16 years was examined. This study is based on information retrieved from the Norwegian Youth Health Surveys (2000–2003) and linked to prescription data from the Norwegian Prescription Database (2004–2013). In total, the study included 10711 participants with a participation rate of 87%. Adolescents were asked how many hours per week they spent on physical activity that made them sweat and/or be out of breath outside of school. Incident psychotropic drug use (outcome measure) was defined as ≥ 1 prescription of one of the following psychotropic drugs: hypnotics and antidepressants registered in the Norwegian Prescription Database. In the crude model for the time period 2004–2007, the odds of incident hypnotic use were lower for those who were physically active 1–2 h per week (OR 0.48–0.64), compared to those who were physically inactive (< 1 h per week). However, the association become non-significant 4-year post-baseline (2008–2010 and 2011–2013). In the crude model for the time periods 2004–2007, 2008–2010 and 2011–2013, the odds of incident antidepressant use were lower for physically active adolescents (2004–2007: OR 0.46–0.71, 2008–2010: OR 0.40–0.67 and 2011–2013: OR 0.37–0.58, compared to those who were physically inactive < 1 h. However, after adjustment for confounders, the association became non-significant in all time periods except in physical activity 5–7 and 8–10 h in the period 2008–2010. Physical activity does not indicate any association with later use of antidepressants, and the significant association with incident hypnotic drug use was for short-term follow-up only and disappeared on longer term follow-up periods. Given the scarcity of longitudinal studies examining the association between physical activity and mental health as well as psychotropic drug use among young people, the current study adds to previous research.
机译：在这项前瞻性研究中，研究了15-16岁青少年的体育锻炼与随后使用抗抑郁药和催眠药之间的关联。这项研究基于从挪威青少年健康调查（2000-2003年）中检索到的信息，并与挪威处方数据库（2004-2013年）中的处方数据相关联。该研究总共包括10711名参与者，参与率为87％。青少年被问及他们每周在运动上花费多少小时，这些运动使他们在学校外流汗和/或气喘吁吁。事件性精神药物的使用（结果度量）被定义为以下精神药物之一的≥1处方：在挪威处方数据库中注册的催眠药和抗抑郁药。在2004-2007年期间的原始模型中，与每周不运动（<1 h）的人相比，每周运动1-2 h（OR 0.48-0.64）的人发生催眠的几率较低每个星期）。但是，该协会在基准后的四年（2008-2010年和2011-2013年）变得无关紧要。在2004-2007年，2008-2010年和2011-2013年期间的粗模型中，参加体育锻炼的青少年使用抗抑郁药的几率较低（2004-2007年：OR 0.46-0.71，2008-2010年：OR 0.40-0.67和2011–2013年：与那些没有身体活动的人相比，OR <1 h。OR 0.37–0.58。但是，在对混杂因素进行调整之后，除了在5-7和8-10h的体育活动中，该关联在所有时间段都变得不显着在2008年至2010年期间，体育锻炼并不表明与以后使用抗抑郁药有任何关联，而与催眠药的使用有关的显着关联仅是短期随访，而在长期随访中消失了。纵向研究缺乏研究年轻人的身体活动与心理健康以及精神药物使用之间的关系，目前的研究增加了以前的研究。

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