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A case of chronic asymptomatic central pontine myelinolysis with histological evidence of remyelination

机译:慢性无症状性桥脑中枢髓鞘溶解伴组织学改变的病例

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摘要

Central pontine myelinolysis (CPM) is a neurological demyelinating disease of the pons. Although usually associated with rapid correction of hyponatremia, CPM may occur despite normonatremia, is often associated with chronic alcoholism and may be asymptomatic. Histological confirmation of asymptomatic CPM is rare. We describe an unusual post-mortem case of extensive but asymptomatic CPM in a chronic alcoholic patient with normonatremia. The affected part of the pons contained thinly myelinated axons with appearances supporting remyelination. We suggest that remyelination may account for the subclinical nature of this patient's CPM.
机译:脑桥中央髓鞘溶解症(CPM)是脑桥的神经脱髓鞘疾病。尽管通常与低钠血症的快速纠正相关,但尽管存在正常性贫血,但CPM可能会发生,通常与慢性酒精中毒有关,并且可能是无症状的。无症状CPM的组织学确认很少。我们描述了在患有正常人的慢性酒精中毒患者中,广泛但无症状的CPM的不寻常验尸病例。桥的受影响部分包含有髓鞘的轴突,外观支持髓鞘再生。我们建议髓鞘再生可解释该患者CPM的亚临床性质。

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