• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Springer Open Choice >Evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (BIMs)
【2h】

Evaluating the ready biodegradability of two poorly water-soluble substances: comparative approach of bioavailability improvement methods (BIMs)

机译：评估两种水溶性差的物质的现成生物降解性：生物利用度改善方法（BIM）的比较方法

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Difficulties encountered in estimating the biodegradation of poorly water-soluble substances are often linked to their limited bioavailability to microorganisms. Many original bioavailability improvement methods (BIMs) have been described, but no global approach was proposed for a standardized comparison of these. The latter would be a valuable tool as part of a wider strategy for evaluating poorly water-soluble substances. The purpose of this study was to define an evaluation strategy following the assessment of different BIMs adapted to poorly water-soluble substances with ready biodegradability tests. The study was performed with two poorly water-soluble chemicals—a solid, anthraquinone, and a liquid, isodecyl neopentanoate—and five BIMs were compared to the direct addition method (reference method), i.e., (i) ultrasonic dispersion, (ii) adsorption onto silica gel, (iii) dispersion using an emulsifier, (iv) dispersion with silicone oil, and (v) dispersion with emulsifier and silicone oil. A two-phase evaluation strategy of solid and liquid chemicals was developed involving the selection of the most relevant BIMs for enhancing the biodegradability of tested substances. A description is given of a BIM classification ratio (RBIM), which enables a comparison to be made between the different test chemical sample preparation methods used in the various tests. Thereby, using this comparison, the BIMs giving rise to the greatest biodegradability were ultrasonic dispersion and dispersion with silicone oil or with silicone oil and emulsifier for the tested solid chemical, adsorption onto silica gel, and ultrasonic dispersion for the liquid one.Electronic supplementary materialThe online version of this article (doi:10.1007/s11356-016-6899-3) contains supplementary material, which is available to authorized users.
机译：在估计水溶性差的物质的生物降解过程中遇到的困难通常与它们对微生物的有限生物利用度有关。已经描述了许多原始的生物利用度改善方法（BIM），但没有提出用于标准化比较这些方法的全局方法。后者将是一种有价值的工具，可作为评估水溶性差的物质的更广泛策略的一部分。这项研究的目的是在评估适用于水溶性差的物质的不同BIM并通过现成的生物降解性测试后，确定一种评估策略。该研究是使用两种水溶性差的化学物质进行的，即固体蒽醌和液体新戊酸异癸酯，并将五个BIM与直接添加方法（参考方法）进行比较，即（i）超声分散，（ii）吸附到硅胶上，（iii）使用乳化剂的分散体，（iv）与硅油的分散体，和（v）与乳化剂和硅油的分散体。制定了固态和液态化学品的两阶段评估策略，其中包括选择最相关的BIM，以增强被测物质的生物降解能力。给出了BIM分类比（RBIM）的描述，该分类比可以在各种测试中使用的不同测试化学样品制备方法之间进行比较。因此，通过这种比较，产生最大生物降解性的BIM为：超声分散和与硅油或与硅油和乳化剂的分散体（用于测试的固体化学品），硅胶的吸附和超声对液体（液体）的分散体。本文的在线版本（doi：10.1007 / s11356-016-6899-3）包含补充材料，授权用户可以使用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号