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首页> 美国卫生研究院文献>Springer Open Choice >Influence of zinc supplementation on histopathological changes in the stomach liver kidney brain pancreas and spleen during subchronic exposure of Wistar rats to glyphosate
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Influence of zinc supplementation on histopathological changes in the stomach liver kidney brain pancreas and spleen during subchronic exposure of Wistar rats to glyphosate

机译：Wistar大鼠亚慢性暴露于草甘膦期间补锌对胃肝肾脑胰腺和脾脏组织病理变化的影响

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A subchronic toxicity study was carried out to determine the glyphosate-induced histopathological changes in the stomach, liver, kidney, brain, pancreas and spleen of rats and the attendant ameliorative effect when pretreated with zinc at the dose rate of 50 mg/kg body weight. The rats were exposed to two doses of the glyphosate (375 and 14.4 mg/kg body weight) for the period of 8 weeks which was the duration of the study, and some groups were exposed to the glyphosate after pretreatment with zinc. The histopathological changes recorded during the study were only in the rats exposed to the glyphosate at the dose rate of 375 mg/kg body weight except the vacuolation encountered in the brains and haemosiderosis in the spleens of rats exposed to zinc alone. Degenerated mucosal epithelial cells which involved the muscularis mucosa and the glands in the stomachs of rats were seen microscopically. Hepatic cells degeneration especially at the portal areas of the livers of rats was observed. The histopathological examination of the kidneys showed glomerular degeneration, mononuclear cells infiltration into the interstices of the tubules and tubular necrosis. The conspicuous changes seen in the brains were neuronal degeneration. Pancreatic acinar cells were degenerated while the spleen of the rats showed depopulated splenic cells in both the red and the white pulps. It was concluded that zinc supplementation in rats prior to glyphosate exposure ameliorated the histopathological changes observed in the stomach, liver, kidney, brain, pancreas and spleen with no observable alteration in the histoarchitecture in the organs of the zinc-supplemented rats.
机译：进行了一项亚慢性毒性研究，以确定草甘膦在大鼠的胃，肝，肾，脑，胰腺和脾脏中引起的组织病理学变化，以及在以50 mg / kg体重的剂量进行锌预处理后伴随的缓解作用。在研究持续的8周内，大鼠接受了两次剂量的草甘膦（375和14.4 mg / kg体重）暴露，一些组在锌预处理后暴露于草甘膦。在研究期间记录的组织病理学变化仅在以375 mg / kg体重的剂量暴露于草甘膦的大鼠中，除了仅暴露于锌的大鼠的大脑中出现的空泡和脾脏铁血病。显微镜下观察到退化的粘膜上皮细胞累及大鼠胃的肌层粘膜和腺体。观察到肝细胞变性，特别是在大鼠肝脏的门户区域。肾脏的组织病理学检查显示肾小球变性，单核细胞浸润到肾小管间隙和肾小管坏死。在大脑中看到的明显变化是神经元变性。胰腺腺泡细胞退化，而大鼠的脾脏在红色和白色牙髓中均显示出脾脏细胞减少。结论是，在草甘膦暴露之前在大鼠中补充锌改善了在胃，肝，肾，脑，胰腺和脾脏中观察到的组织病理学变化，而在补充锌的大鼠器官中组织结构没有可观察到的变化。

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