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首页> 外文会议>International Conference on Biomedical and Biological Engineering >Influence of Tonifying Kidney and Spleen, Detoxification of Throat Method to MMP-9, TIMP-1 of IgA Nephropathy Model Rat
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Influence of Tonifying Kidney and Spleen, Detoxification of Throat Method to MMP-9, TIMP-1 of IgA Nephropathy Model Rat

机译：调整肾脏和脾，咽喉溶解对IGA肾病模型大鼠MMP-9的影响

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Purpose: To study the method of tonifying kidney and spleen, detoxification of throat in treatment of IgA nephropathy. Methods:72 Wistar rats were randomly divided into blank group, model group, Lotensin group, tonifying the kidney and spleen, detoxification of method of high, medium and low dose group (hereinafter referred to as TCM high, medium and low dose group). The IgAN rat model was established by oral administration of BSA and LPS intravenous injection method. Observed after treatment for 8 weeks rats in each phase of urine red blood cell count, 24h urinary protein (UTP) and renal tissue MMP-9, TIMP-1 changes. Results:1) compared with the model group, rats 24h UTP has declined. The TCM medium dose group decreased significantly (P<0.05); 2) compared with the model group, TCM in the treatment group the urine red blood cell count decreased significantly (P<0.05). TCM medium dose group decreased significantly (P<0.01); urinary red blood cell of lotensin group decreased (P>0.05). 3) compared with the blank group, the content of MMP-9 in renal tissue of the rats in the model group decreased significantly, the content of TIMP-1 increased significantly, and MMP-9/TIMP-1 decreased (P<0.05); 4) after taking drug, compared with the model group, treatment group content of MMP-9 significantly increased and TIMP-1 levels were significantly lower and MMP-9/TIMP-1 significantly increased (P<0.05). TCM medium dose group was most significantly (P<0.01). Conclusion:Tonifying kidney and spleen, detoxification of throat method can reduce the IgAN model rats with hematuria, proteinuria and increase MMP-9 and reduce the TIMP-1 in renal tissue, and MMP-9/TIMP-1 tends to be balance, the curative effect is better than that of Lotensin group.
机译：目的：研究调整肾脏和脾脏，咽喉中的解毒治疗IGA肾病。方法：将72只Wistar大鼠随机分为空白组，模型组，莲素组，调整肾脏和脾脏，高剂量组和低剂量组方法的解毒（以下称为TCM高，中低剂量组）。通过口服BSA和LPS静脉注射方法建立IgAn大鼠模型。在治疗后8周大鼠在尿红细胞计数的每一阶段，24h尿蛋白（UTP）和肾组织MMP-9，TIMP-1变化。结果：1）与模型组相比，大鼠24H UTP已下降。 TCM培养基剂量组显着下降（P <0.05）; 2）与模型组相比，治疗组中的TCM尿红细胞计数显着下降（P <0.05）。中医培养基剂量显着下降（P <0.01）;莲素组的尿红血细胞减少（p> 0.05）。 3）与空白组相比，模型组大鼠肾组织中MMP-9的含量显着下降，TIMP-1的含量显着增加，MMP-9 / TIMP-1减少（P <0.05） ; 4）服用药物后，与模型组相比，MMP-9的治疗组含量显着增加，TIMP-1水平显着降低，MMP-9 / TIMP-1显着增加（P <0.05）。 TCM中剂量组最显着（P <0.01）。结论：调整肾脏和脾脏，咽喉解毒可以减少血尿，蛋白尿和增加MMP-9的IGAN模型大鼠，减少肾组织中的TIMP-1，MMP-9 / TIMP-1趋于平衡，疗效优于莲素组的疗效。

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