首页> 外国专利> USE OF SERUM 2-CYSTEINE PEROXIREDOXINS (2-CYS-PRDX) AS BIOMARKERS OF CHRONIC KIDNEY DISEASES (CKD) SUCH AS LUPUS NEPHRITIS (LN), IGA NEPHROPATHY (IGAN) AND AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) USEFUL FOR DIAGNOSING, MONITORING, AND PROGNOSING IN THESE DISEASES AND METHOD OF DIFFERENTIATION OF THESE DISEASES

USE OF SERUM 2-CYSTEINE PEROXIREDOXINS (2-CYS-PRDX) AS BIOMARKERS OF CHRONIC KIDNEY DISEASES (CKD) SUCH AS LUPUS NEPHRITIS (LN), IGA NEPHROPATHY (IGAN) AND AUTOSOMAL-DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD) USEFUL FOR DIAGNOSING, MONITORING, AND PROGNOSING IN THESE DISEASES AND METHOD OF DIFFERENTIATION OF THESE DISEASES

机译：血清2-半胱氨酸过氧化物酶（2-CYS-PRDX）作为慢性肾脏疾病（CKD）的生物标志物，如狼疮性肾炎（LN），IGA肾病（IGAN）和常染色体多态性肾病（ADPKD）用于治疗这些疾病的监测和预测以及这些疾病的鉴别方法

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摘要

The resent invention relates to the use of at least one of 2-Cys-PRDXs selected from a group consisting of PRDX1, PRDX2, PRDX3, PRDX4 and PRDX5 as a biomarker to diagnose, differentiate and/or assess the risk of chronic kidney disease (CDK). Present invention also relates to the method of diagnosis and the method of determining an increased risk of chronic kidney disease (CKD). Present invention also provides a kit suitable for diagnosis and differentiation of chronic kidney disease (CKD) selected from the group comprising lupus nephritis (LN), IgA nephropathy (IgAN) and autosomal-dominant polycystic kidney disease (ADPKD) in a subject.

机译：本发明涉及选自PRDX1，PRDX2，PRDX3，PRDX4和PRDX5的2-Cys-PRDX中的至少一种作为生物标记物用于诊断，区分和/或评估慢性肾脏疾病的风险的用途（ CDK）。本发明还涉及诊断方法和确定慢性肾脏病（CKD）风险增加的方法。本发明还提供了一种适于在受试者中诊断和区分慢性肾脏疾病（CKD）的试剂盒，所述慢性肾脏疾病选自狼疮性肾炎（LN），IgA肾病（IgAN）和常染色体显性多囊性肾脏病（ADPKD）。

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公开/公告号EP3358355A1

专利类型
公开/公告日2018-08-08

原文格式PDF
申请/专利权人 WARSZAWSKI UNIWERSYTET MEDYCZNY;
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申请/专利号EP20170461508
发明设计人 MUCHA KRZYSZTOF;ZAGOZDZON RADOSLAW;FORONCEWICZ BARTOSZ;PACZEK LESZEK;KRATA NATALIA;GALA KAMILA;
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申请日2017-02-04
分类号G01N33/68;G01N33/564;
国家 EP
入库时间 2022-08-21 13:15:03

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