• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Comparative Medicine >Urinary Biomarkers for Monitoring Disease Progression in the Han:SPRD-cy Rat Model of Autosomal-Dominant Polycystic Kidney Disease
【24h】

Urinary Biomarkers for Monitoring Disease Progression in the Han:SPRD-cy Rat Model of Autosomal-Dominant Polycystic Kidney Disease

机译：监测汉族常染色体显性多囊肾疾病模型的疾病进展的尿液生物标志物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The Han SRPD-cy rat is a well-recognized model of human autosomal-dominant polycystic kidney disease The disease is characterized by the development of progressive renal cysts, leading to declining renal function Disease progression typically is monitored by measurement of plasma urea concentration Although plasma urea may be an adequate measure of overall renal function, urinary biomarkers capable of accurately monitoring disease progression may be equally useful The goal of this study was to assess several urinary biomarkers as potential markers of disease progression in male and female Han SPRD-cy rats These biomarkers were compared with changes in plasma urea concentration and morphometric changes as the disease progressed Urinary activity of N-acetyl-beta-D-glucosaminidase and concentration of a-glutathione S-transferase were measured as markers of proximal tubular dysfunction, glutathione S-transferase Yb1 as a distal tubular marker, and collagen IV as a biomarker for glomerular lesions Urinary albumin was used as biomarker of glomerular or proximal tubular lesions Albuminuria increased in male rats as the disease progressed, correlating with increasing plasma urea and morphologic changes Urine concentrations of alpha-glutathione S-transferase decreased significantly in the male heterozygotic compared with wildtype rats in the later stages of the disease Urinary concentrations of glutathione S-transferase Yb1 and collagen IV and activity of N-acetyl-beta-D-glucosaminidase did not change during disease progression Measurement of urinary albumin and concentrations of alpha-glutathione S-transferase may be useful for monitoring disease progression in the male Han SPRD-cy rat model in future experiments
机译：Han SRPD-cy大鼠是公认的人类常染色体显性遗传多囊性肾脏疾病模型。该疾病的特征是进行性肾囊肿的发展，导致肾功能下降。疾病进展通常通过测量血浆尿素浓度来监测。尿素可能是整体肾功能的适当量度，能够准确监测疾病进展的尿液生物标志物可能同样有用。本研究的目的是评估几种尿液生物标志物，作为雄性和雌性汉族SPRD-cy大鼠疾病进展的潜在标志物。将生物标志物与疾病进展过程中血浆尿素浓度和形态变化的变化进行比较，测量尿液中N-乙酰基-β-D-氨基葡萄糖苷酶的活性，并测量a-谷胱甘肽S-转移酶的浓度作为近端肾小管功能障碍，谷胱甘肽S-转移酶的标志Yb1是远端肾小管标志物，胶原IV是肾小球的生物标志物病损尿白蛋白被用作雄性大鼠肾小球或近端肾小管病损的生物标志物随着疾病的进展，白蛋白尿增加，与血浆尿素的增加和形态学改变相关在疾病晚期，在疾病进展过程中，尿中谷胱甘肽S-转移酶Yb1和胶原蛋白IV的浓度以及N-乙酰基-β-D-氨基葡萄糖苷酶的活性没有变化。尿白蛋白和α-谷胱甘肽S-转移酶的浓度可能在未来的实验中可用于监测雄性汉族SPRD-cy大鼠模型的疾病进展

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号