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首页> 美国卫生研究院文献>Springer Open Choice >Striatal volume is related to phonemic verbal fluency but not to semantic or alternating verbal fluency in early Parkinson’s disease
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Striatal volume is related to phonemic verbal fluency but not to semantic or alternating verbal fluency in early Parkinson’s disease

机译：纹状体体积与早期帕金森氏病的语音口语流利度有关但与语义或交替口语流利度无关

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Verbal fluency impairments are frequent in Parkinson’s disease (PD) and they may be present already at early stages. Semantic fluency impairment is associated with Parkinson’s disease dementia and temporal, frontal and cerebellar cortical changes. Few studies have addressed cerebral structural correlates of different verbal fluency tasks in early stage PD. We therefore studied gray matter volumes of T1-weighted MRI images using voxel-based morphometry in relation to semantic, phonemic, and alternating verbal fluency in younger (mean age <65 years), early stage (mean disease duration <3 years), non-demented PD patients (n = 28) and healthy controls (n = 27). We found a significant association between worse phonemic fluency and smaller striatal, namely right caudate gray matter volume in the PD group only (family-wise error corrected p = 0.007). Reduced semantic fluency was associated with smaller gray matter volumes in left parietal cortex (p = 0.037) and at trend level with smaller bilateral cerebellum gray matter volume across groups (p = 0.062), but not in the separate PD or control groups. There were no significant relationships between alternating fluency and gray matter volumes in the whole sample or in the groups separately. The fact that phonemic fluency, but not semantic or alternating fluency, was associated with caudate gray matter volume at early stage PD suggests that different fluency tasks rely on different neural substrates, and that language networks supporting semantic search and verbal-semantic switching are unrelated to brain gray matter volume at early disease stages in PD.
机译：帕金森氏病（PD）中经常出现口语流利度障碍，并且可能早已出现。语义流畅性障碍与帕金森氏病痴呆症以及颞，额和小脑皮质变化有关。很少有研究解决早期PD中不同口语流利度任务的大脑结构相关性。因此，我们使用基于体素的形态计量学研究了T1加权MRI图像的灰质体积，并将其与年幼（平均年龄<65岁），早期（平均疾病持续时间<3岁），非早期的语义，语音和交替语言流利度相关痴呆的PD患者（n = 28）和健康对照（n = 27）。我们发现较差的音素流利度和较小的纹状体之间存在显着相关性，即仅在PD组中右尾状灰质体积较大（校正了家族性误差p = 0.007）。语义流畅性的降低与左顶叶皮层中较小的灰质体积（p = 0.037）和趋势水平上各组的双侧小脑灰质体积较小（p = 0.062）有关，但在单独的PD或对照组中则没有。在整个样品中或在单独的组中，交替流利度和灰质体积之间没有显着关系。语音的流利性而不是语义的或交替的流利性与早期PD的尾状灰质量相关联的事实表明，不同的流利性任务依赖于不同的神经底物，并且支持语义搜索和言语-语义转换的语言网络与PD疾病早期阶段的脑灰质体积。

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