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Brain penetration of the OAB drug trospium chloride is not increased in aged mice

机译：OAB药物氯化氯化钾的大脑渗透率在老年小鼠中并未增加

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PurposeTo analyse whether the permeability of the blood–brain barrier to the antimuscarinic drug trospium chloride is altered with ageing. This is a relevant question for elderly patients with overactive bladder syndrome who are treated with trospium chloride as the occurrence of adverse effects on the central nervous system (CNS) highly depends on the absolute drug concentration in the brain.

机译：目的分析抗衰老药物抗毒蕈碱药物氯化钾的血脑屏障通透性是否随年龄的增长而改变。对于患有过动性膀胱综合征的老年患者，他们需要接受氯化钾处理，因为对中枢神经系统（CNS）的不良反应的发生很大程度上取决于大脑中的绝对药物浓度，因此这是一个相关的问题。

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期刊名称 Springer Open Choice
作者
Jasmin Kranz; Ernst Petzinger; Joachim Geyer;
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作者单位

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年(卷),期 -1(31),1
年度 -1
页码 219–224
总页数 6
原文格式 PDF
正文语种
中图分类外科学;
关键词
Trospium chloride Transport Blood–brain barrier P-glycoprotein Ageing;

机译：氯化钙;运输;血脑屏障;P-糖蛋白;衰老;

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专利

1. Brain penetration of the OAB drug trospium chloride is not increased in aged mice [J] . KranzJ., PetzingerE., GeyerJ. World journal of urology . 2013,第1期

机译：OAB药物氯化钾的脑部渗透率在老年小鼠中并未增加
2. The role of p-glycoprotein in limiting brain penetration of the peripherally acting anticholinergic overactive bladder drug trospium chloride. [J] . Geyer J, Gavrilova O, Petzinger E Drug Metabolism and Disposition: The Biological Fate of Chemicals . 2009,第7期

机译：p-糖蛋白在限制外周作用的抗胆碱能过度活跃的膀胱药物氯化钾中的作用。
3. Trospium chloride once-daily extended release is effective and well tolerated in elderly patients (aged 75 years and over) with overactive bladder (OAB) [J] . International urogynecology journal and pelvic floor dysfunction . 2008,第Suppla1期

机译：氯化钾每天一次的缓释对患有膀胱过度活动症（OAB）的老年患者（75岁及以上）有效且耐受良好
4. Anti-tumor and repairing nerve injuries: A drug-loaded monosialoganliosides micelles delivered to brain for glioblastoma [C] . Dan Zou, Yazhou Wang, Zong Li, World biomaterials congress . 2016

机译：抗肿瘤和修复神经损伤：载有药物的单唾液酸神经节苷脂胶束被递送至脑胶质母细胞瘤
5. Acute Post-Ischemic Seizures are Associated with Increased Mortality and Brain Damage Following Hypoxia-Ischemia in Adult Mice [D] . El-Hayek, Youssef Hanna 2011

机译：急性后缺血癫痫发作与成年小鼠缺氧缺血后的死亡率和脑损伤增加有关
6. Image-Guided Treatment of Primary Liver Cancer in Mice Leads to Vascular Disruption and Increased Drug Penetration [O] . Sara B. Keller, Dingjie Suo, Yak-Nam Wang, 2020

机译：原发性肝癌在小鼠中的图像引导治疗导致血管破坏和增加的药物渗透
7. Brain penetration of the OAB drug trospium chloride is not increased in aged mice [O] . Jasmin Kranz, Ernst Petzinger, Joachim Geyer 2011

机译：OAB药物氯化氯化钾的大脑渗透率在老年小鼠中并未增加

Brain penetration of the OAB drug trospium chloride is not increased in aged mice

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