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首页> 美国卫生研究院文献>Springer Open Choice >Ambient particulate air pollution and acute lower respiratory infections: a systematic review and implications for estimating the global burden of disease
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Ambient particulate air pollution and acute lower respiratory infections: a systematic review and implications for estimating the global burden of disease

机译：环境空气污染和急性下呼吸道感染：系统评价及其对估计全球疾病负担的影响

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摘要

Acute lower respiratory infections (ALRI) account for nearly one fifth of mortality in young children worldwide and have been associated with exposures to indoor and outdoor sources of combustion-derived air pollution. A systematic review was conducted to identify relevant articles on air pollution and ALRI in children. Using a Bayesian approach to meta-analysis, a summary estimate of 1.12 (1.03, 1.30) increased risk in ALRI occurrence per 10 μg/m3 increase in annual average PM2.5 concentration was derived from the longer-term (subchronic and chronic) effects studies. This analysis strengthens the evidence for a causal relationship between exposure to PM2.5 and the occurrence of ALRI and provides a basis for estimating the global attributable burden of mortality due to ALRI that is not influenced by the wide variation in regional case fatality rates. Most studies, however, have been conducted in settings with relatively low levels of PM2.5. Extrapolating their results to other, more polluted, regions will require a model that is informed by evidence from studies of the effects on ALRI of exposure to PM2.5 from other combustion sources, such as secondhand smoke and household solid fuel use.
机译：急性下呼吸道感染（ALRI）占全世界幼儿死亡率的近五分之一，并与暴露于室内和室外燃烧源空气污染有关。进行了系统的审查，以确定有关儿童空气污染和ALRI的相关文章。使用贝叶斯方法进行荟萃分析，可以得出以下结论：年平均PM2.5浓度每增加10μg/ m 3 ，ALRI发生风险增加1.12（1.03，1.30）。长期（亚慢性和慢性）影响研究。这项分析加强了PM2.5暴露与ALRI发生之间因果关系的证据，并为估算ALRI引起的全球归因死亡负担提供了基础，该负担不受区域病死率的广泛差异影响。但是，大多数研究都是在PM2.5含量相对较低的环境中进行的。将其结果推断到其他污染更严重的地区，将需要一个模型，该模型的研究证据来自其他燃烧源（例如二手烟和家用固体燃料使用）暴露于PM2.5对ALRI的影响。

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