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首页> 美国卫生研究院文献>Springer Open Choice >Total laparoscopic hysterectomy versus total abdominal hysterectomy with bilateral salpingo-oophorectomy for endometrial carcinoma: a randomised controlled trial with 5-year follow-up
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Total laparoscopic hysterectomy versus total abdominal hysterectomy with bilateral salpingo-oophorectomy for endometrial carcinoma: a randomised controlled trial with 5-year follow-up

机译：全腹腔镜子宫切除术与全腹子宫切除术联合双侧输卵管卵巢切除术治疗子宫内膜癌：5年随访的随机对照试验

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This report is on recovery and long-term outcomes in a small-scale randomised controlled trial (RCT) after total laparoscopic hysterectomy versus total abdominal hysterectomy in (potential) endometrial carcinoma patients. An RCT was performed among women with atypical endometrial hyperplasia and endometrial carcinoma scheduled for hysterectomy in a teaching hospital in The Netherlands. Women were randomised to total laparoscopic hysterectomy versus total abdominal hysterectomy both with bilateral salpingo-oophorectomy and were followed until 5 years after the intervention. Patients completed the RAND 36-Item Short Form Health Survey (RAND-36), Quality of Recovery-40 (QoR-40) and Recovery Index-10 (RI-10) until 12 weeks after surgery. Main outcome measure was quality of life and recovery in the first 12 weeks after surgery. A linear mixed model was used for statistical analysis while accounting for baseline values where applicable. Seventeen women were included, of whom 11 allocated to the laparoscopic arm and 6 to the abdominal arm. Laparoscopic hysterectomy performed better on all scales and subscales used in the study. A statistically significant treatment effect, favouring laparoscopic hysterectomy, was found in the total RAND-36 (difference between groups 142 units, 95% confidence interval 46; 236). Clinical follow-up was completed after median 60 months, but this study was too small for conclusions regarding the safety and survival. Laparoscopic hysterectomy results in better postoperative quality of life in the first 12 weeks after surgery when compared with abdominal hysterectomy.
机译：该报告是关于（潜在）子宫内膜癌患者全腹腔镜子宫切除术与全腹子宫切除术后的小型随机对照试验（RCT）的恢复和长期结果。在荷兰的一家教学医院中，对有异型子宫内膜增生和子宫内膜癌的女性行子宫切除术进行了RCT。将女性随机分为双侧输卵管卵巢切除术和全腹腔镜子宫切除术与全腹子宫切除术，并随访至干预后5年。患者在手术后12周之前完成了RAND 36项简短健康调查（RAND-36），恢复质量40（QoR-40）和恢复指数10（RI-10）。主要结局指标是术后头12周的生活质量和恢复情况。使用线性混合模型进行统计分析，同时在适用时考虑基线值。其中包括17名妇女，其中11名分配给腹腔镜臂，6名分配给腹臂。腹腔镜子宫切除术在本研究中使用的所有量表和亚量表上均表现更好。在总的RAND-36中发现了统计学上显着的治疗效果，有利于腹腔镜子宫切除术（组间142个单位之间的差异，95％置信区间46； 236）。中位60个月后完成了临床随访，但该研究规模太小，无法得出有关安全性和生存率的结论。与腹腔子宫切除术相比，腹腔镜子宫切除术可在术后头12周提供更好的术后生活质量。

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