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Prevention of allergy by virus‐like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model

机译：通过病毒样纳米颗粒（VNP）预防过敏在人源化鼠类过敏模型中提供主要过敏原的屏蔽版本

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BackgroundIn high‐risk populations, allergen‐specific prophylaxis could protect from sensitization and subsequent development of allergic disease. However, such treatment might itself induce sensitization and allergies, thus requiring hypoallergenic vaccine formulations. We here characterized the preventive potential of virus‐like nanoparticles (VNP) expressing surface‐exposed or shielded allergens.

机译：背景在高风险人群中，预防过敏原可以防止过敏性疾病的致敏和随后的发展。但是，这种治疗本身可能会引起过敏和过敏，因此需要低过敏性疫苗制剂。我们在这里描述了表达表面暴露或屏蔽的过敏原的类病毒纳米颗粒（VNP）的预防潜力。

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期刊名称 Wiley-Blackwell Online Open
作者
Bernhard Kratzer; Cordula Köhler; Sandra Hofer; Ursula Smole; Doris Trapin; Jagoba Iturri; Dietmar Pum; Philip Kienzl; Adelheid Elbe‐Bürger; Pia Gattinger; Irene Mittermann; Birgit Linhart; Gabriele Gadermaier; Beatrice Jahn‐Schmid; Alina Neunkirchner; Rudolf Valenta; Winfried F. Pickl;
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年(卷),期 -1(74),2
年度 -1
页码 246–260
总页数 15
原文格式 PDF
正文语种
中图分类
关键词
allergy prevention mugwort pollen allergy Treg cells virus‐like nanoparticles prevention lung APC;

机译：预防过敏;艾蒿花粉过敏;Treg细胞;病毒样纳米颗粒;预防;肺APC;

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专利

1. Prevention of allergy by virus-like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model [J] . Kratzer Bernhard, Koehler Cordula, Hofer Sandra, Allergy . 2019,第2期

机译：用病毒样纳米粒子（VNP）预防过敏（VNP）在人源鼠过敏模型中递送屏蔽版的主要过敏原
2. Protective effect of the DNA vaccine encoding the major house dust mite allergens on allergic inflammation in the murine model of house dust mite allergy [J] . Nacksung Kim, Soon S Kwon, Jaechun Lee, Clinical and Molecular Allergy . 2006,第1期

机译：编码主要屋尘螨过敏原的DNA疫苗在屋尘螨过敏性小鼠模型中对过敏性炎症的保护作用
3. Suppression of antigen-specific T- and B-cell responses by intranasal or oral administration of recombinant bet v 1, the major birch pollen allergen, in a murine model of type I allergy. [J] . Wiedermann U, Jahn Schmid-B, Bohle B, The Journal of Allergy and Clinical Immunology . 1999,第6期

机译：在I型变态反应的鼠模型中，通过鼻内或口服施用重组投注v 1（主要的桦树花粉变应原）来抑制抗原特异性T细胞和B细胞反应。
4. Dust mite allergens: A major risk factor in development of allergies in Dubai [C] . Sultan D.M., Khalil M.M. European Multicolloquium of Parasitology Congress . 2012

机译：尘埃螨过敏原：迪拜过敏发展的主要危险因素
5. Using BALB/c mice as a model of food allergy to study gene expression profiles in response to common food allergens. [D] . Husain, Mainul. 2010

机译：使用BALB / c小鼠作为食物过敏的模型来研究对常见食物过敏原的基因表达谱。
6. Allergen-specific immunosuppression by mucosal treatment with recombinant Ves v 5 a major allergen of Vespula vulgaris venom in a murine model of wasp venom allergy [O] . Birgit Winkler, Caroline Bolwig, Ulla Seppälä, 2003

机译：在黄蜂毒液过敏的鼠模型中通过重组Ves v 5的粘膜处理对过敏原进行特异性免疫抑制Ves v 5是寻常黄蜂毒液的主要过敏原
7. Prevention of allergy by virus-like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model [O] . Bernhard Kratzer, Cordula Köhler, Sandra Hofer, 2018

机译：用病毒样纳米粒子（VNP）预防过敏（VNP）在人源鼠过敏模型中提供屏蔽版的主要过敏原

Prevention of allergy by virus‐like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model

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