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Identification of barriers to insulin therapy and approaches to overcoming them

机译:识别胰岛素治疗的障碍及其克服方法

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摘要

Poor glycaemic control in type 2 diabetes (T2D) is a global problem despite the availability of numerous glucose‐lowering therapies and clear guidelines for T2D management. Tackling clinical or therapeutic inertia, where the person with diabetes and/or their healthcare providers do not intensify treatment regimens despite this being appropriate, is key to improving patients’ long‐term outcomes. This gap between best practice and current level of care is most pronounced when considering insulin regimens, with studies showing that insulin initiation/intensification is frequently and inappropriately delayed for several years. Patient‐ and physician‐related factors both contribute to this resistance at the stages of insulin initiation, titration and intensification, impeding achievement of optimal glycaemic control. The present review evaluates the evidence and reasons for this delay, together with available methods for facilitation of insulin initiation or intensification.
机译:尽管有许多降低血糖的疗法和明确的T2D管理指南,但2型糖尿病(T2D)的血糖控制不良仍然是一个全球性问题。应对临床或治疗惯性,这是糖尿病患者和/或其医疗保健提供者尽管适当的情况下仍不加强治疗方案的方法,对改善患者的长期疗效至关重要。在考虑胰岛素治疗方案时,最佳实践和当前护理水平之间的差距最为明显,研究表明,胰岛素的开始/强化频繁且不适当地延迟了数年。在胰岛素起始,滴定和强化阶段,患者和医师相关因素均会导致这种耐药性,从而阻碍最佳血糖控制的实现。本综述评估了这种延迟的证据和原因,以及促进胰岛素起始或强化的可用方法。

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